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首页> 外文期刊>Journal of Investigative Dermatology Symposium Proceedings >Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair
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Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair

机译：角质形成细胞生长因子和激活素在皮肤形态发生和皮肤创面修复中的表达和功能

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Reepithelialization and granulation tissue formation during cutaneous wound repair are mediated by a wide variety of growth and differentiation factors. Recent studies from our laboratory provided evidence for an important role of keratinocyte growth factor (KGF) in the repair of the injured epithelium and for a novel function of the transforming growth factor- superfamily member activin in granulation tissue formation. KGF is weakly expressed in human skin, but is strongly upregulated in dermal fibroblasts after skin injury. Its binding to a transmembrane receptor on keratinocytes induces proliferation and migration of these cells. Furthermore, KGF has been shown to protect epithelial cells from the toxic effects of reactive oxygen species. We have identified a series of KGF-regulated genes that are likely to play a role in these processes. In addition to KGF, activin seems to be a novel player in wound healing. Activin expression is hardly detectable in nonwounded skin, but this factor is highly expressed in redifferentiating keratinocytes of the hyperproliferative wound epithelium as well as in cells of the granulation tissue. To gain insight into the role of activin in wound repair, we generated transgenic mice that overexpress activin in basal keratinocytes of the epidermis. These mice were characterized by a hyperthickened epidermis and by dermal fibrosis. Most importantly, overexpression of activin strongly enhanced the process of granulation tissue formation, demonstrating a novel and important role of activin in cutaneous wound repair.
机译：皮肤伤口修复期间的上皮形成和肉芽组织形成是由多种生长和分化因子介导的。我们实验室的最新研究提供了证据，证明了角质形成细胞生长因子（KGF）在修复受损上皮中的重要作用，以及转化生长因子超家族成员激活素在肉芽组织形成中的新功能。 KGF在人皮肤中微弱表达，但在皮肤损伤后在皮肤成纤维细胞中强烈上调。它与角质形成细胞上的跨膜受体结合会诱导这些细胞的增殖和迁移。此外，已证明KGF可保护上皮细胞免受活性氧的毒性作用。我们已经鉴定出一系列可能在这些过程中起作用的KGF调控基因。除KGF以外，激活素似乎是伤口愈合的新参与者。在未受伤的皮肤中几乎检测不到激活素的表达，但是该因子在过度增生性伤口上皮的再分化角质形成细胞以及肉芽组织的细胞中高度表达。为了深入了解激活素在伤口修复中的作用，我们生成了在表皮基底角质形成细胞中过表达激活素的转基因小鼠。这些小鼠的特征是表皮超厚和皮肤纤维化。最重要的是，激活素的过表达强烈增强了肉芽组织形成的过程，证明了激活素在皮肤创面修复中具有新颖而重要的作用。

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