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首页> 外文期刊>Journal of Korean medical science. >Enhanced neutrophil functions by recombinant human granulocyte colony-stimulating factor in diabetic patients with foot infections in vitro
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Enhanced neutrophil functions by recombinant human granulocyte colony-stimulating factor in diabetic patients with foot infections in vitro

机译：重组人粒细胞集落刺激因子增强糖尿病足病患者的中性粒细胞功能

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This study was performed to evaluate the effect of granulocyte-colony stimulating factor on neutrophil functions in diabetic patients with active foot infections in vitro. Twelve diabetic patients with foot infections and 12 normal volunteers were enrolled. Neutrophils from peripheral blood were incubated with granulocyte colony-stimulating factor (G-CSF, 50 ng/mL) for 20 min. Superoxide production of neutrophils was measured by the reduction of ferricytochrome C. Neutrophil phagocytosis was assayed using Staphylococcus aureus and the weighted phagocytic index was calculated. Superoxide production of neutrophils in diabetic patients with foot infections was 7.7 (unit: nmol/2 × 105 cells/60 min), which was significantly lower than that in controls (12.0) ( p
机译：进行这项研究以评估粒细胞集落刺激因子对患有活动性足部感染的糖尿病患者中性粒细胞功能的影响。招募了12名糖尿病患者的足部感染和12名正常志愿者。将外周血中性粒细胞与粒细胞集落刺激因子（G-CSF，50 ng / mL）孵育20分钟。中性粒细胞超氧化物的产生是通过减少铁细胞色素C来测定的。使用金黄色葡萄球菌检测中性粒细胞的吞噬作用，并计算加权吞噬指数。在患有足部感染的糖尿病患者中，中性粒细胞的超氧化物生成为7.7（单位：nmol / 2×10 5 细胞/ 60分钟），显着低于对照组（12.0）（p

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