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首页> 外文期刊>Journal of Korean medical science. >Kind and Estimated Stocking Amount of Antidotes for Initial Treatment for Acute Poisoning at Emergency Medical Centers in Korea
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Kind and Estimated Stocking Amount of Antidotes for Initial Treatment for Acute Poisoning at Emergency Medical Centers in Korea

机译：在韩国紧急医疗中心进行初步治疗的急性中毒解毒药的种类和估计库存量

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Antidotes for toxicological emergencies can be life-saving. However, there is no nationwide estimation of the antidotes stocking amount in Korea. This study tried to estimate the quantities of stocking antidotes at emergency department (ED). An expert panel of clinical toxicologists made a list of 18 emergency antidotes. The quantity was estimated by comparing the antidote utilization frequency in a multicenter epidemiological study and the nation-wide EDs' data of National Emergency Department Information System (NEDIS). In an epidemiological study of 11 nationwide EDs from January 2009 to December 2010, only 92 (1.9%) patients had been administered emergency antidotes except activated charcoal among 4,870 cases of acute adult poisoning patients. Comparing with NEDIS data, about 1,400,000 patients visited the 124 EDs nationwide due to acute poisoning and about 103,348 adult doses of the 18 emergency antidotes may be required considering poisoning severity score. Of these, 13,224 (1.9%) adult doses of emergency antidotes (575 of atropine, 144 of calcium gluconate or other calcium salts, 2,587 of flumazenil, 3,450 of N -acetylcysteine, 5,893 of pralidoxime, 287 of hydroxocobalamin, 144 of sodium nitrite, and 144 of sodium thiosulfate) would be needed for maintaining the present level of initial treatment with emergency antidotes at EDs in Korea. Graphical Abstract
机译：毒理学紧急情况的解毒剂可以挽救生命。但是，韩国尚无全国范围内解毒剂库存量的估计。这项研究试图估计急诊科（ED）的解毒药库存量。临床毒理学家专家小组列出了18种紧急解毒剂。通过比较多中心流行病学研究中解毒剂的利用频率和国家急诊信息系统（NEDIS）在全国范围内的EDs数据，估算出该药物的使用量。在2009年1月至2010年12月对11个全国ED进行的流行病学研究中，在4870例急性成人中毒患者中，只有92例（1.9％）患者接受了除活性炭外的紧急解毒剂治疗。与NEDIS数据相比，全国约有1,400,000名患者因急性中毒而去了124 ED，考虑到中毒严重程度评分，可能需要约103,348剂成人剂量的18种紧急解毒剂。其中，成人有13224（1.9％）的应急解毒剂（阿托品575，葡萄糖酸钙或其他钙盐144，氟马西尼2587，N-乙酰半胱氨酸3450，普利多肟5893，羟考钴胺287，亚硝酸钠144，为了维持目前在韩国急诊室使用紧急解毒剂进行初始治疗的水平，将需要144克硫代硫酸钠）。图形概要

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