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首页> 外文期刊>Journal of Krishna Institute of Medical Sciences University. >Antimicrobial Resistance Pattern and Frequency of Multiple-Drug Resistant Enterobacter Spp. at A Tertiary Care Hospital in Southwest of Iran.
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Antimicrobial Resistance Pattern and Frequency of Multiple-Drug Resistant Enterobacter Spp. at A Tertiary Care Hospital in Southwest of Iran.

机译：多种耐药肠杆菌属细菌的耐药性模式和频率。在伊朗西南部的第三级医院。

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Background: Strains belonging to Enterobacter genus are important opportunistic nosocomial pathogens. Resistance to broad-spectrum antibiotics often complicates the treatment of Enterobacter infections. Aim and Objectives: The present study was aimed to determine the frequency and antibiotic resistance patterns of Enterobacter spp. obtained from a specialized Women's and Children's hospital. Material and Methods: This retrospective study was conducted during September 2015 to July 2016 in Shiraz, Iran. Enterobacter isolates were obtained from various clinical specimens and were identified using standard microbiologica l proce dure. Antim icrobial susceptibility patterns were determined in accordance with CLSI recommendation. Results: Out of 61 Enterobacter spp., majority of isolates were obtained from blood 11 (18%) and followed by urine and eye specimens (11.5%). Antibiotic susceptibility revealed that all isolates were resistance to amikacin, and mostly resistance to cefotaxim and gentamycin with 90.2% and 75.4%, respectively. The highest sensitivity was toward polymyxin B 96.7%, co-trimoxazole 65.6% and imipenem 57.4%. Overall, the rate of Multiple Drug Resistant (MDR) isolates were 91.8% (n=56). Of MDR isolates, 39.2% of isolates were resistance to at least 3 antibiotics. Conclusion: Despite the significant role of MDR isolates in occurrence of infections, several locally available antibiotics still can have promising effects on outcome of Enterobacter infections in pregnant women and neonates .
机译：背景：属于肠杆菌属的菌株是重要的机会性医院病原体。对广谱抗生素的耐药性通常会使肠杆菌感染的治疗复杂化。目的和目的：本研究旨在确定肠杆菌属的频率和抗生素耐药性模式。从一家专门的妇女儿童医院获得。材料和方法：这项回顾性研究于2015年9月至2016年7月在伊朗设拉子进行。从各种临床标本中分离出肠杆菌，并使用标准微生物学方法对其进行鉴定。根据CLSI的建议确定抗菌药物的敏感性模式。结果：在61种肠杆菌属中，大多数分离物来自血液11（18％），其次是尿液和眼标本（11.5％）。抗生素敏感性表明，所有分离株均对阿米卡星具有抗药性，且大多数对头孢噻菌胺和庆大霉素具有抗药性，分别为90.2％和75.4％。对多粘菌素B的敏感性最高，为96.7％，三甲恶唑为65.6％，亚胺培南为57.4％。总体而言，耐多药（MDR）分离株的比率为91.8％（n = 56）。在MDR分离株中，有39.2％的分离株对至少3种抗生素具有抗药性。结论：尽管MDR分离物在感染的发生中起着重要作用，但几种本地可用的抗生素仍可对孕妇和新生儿的肠杆菌感染的结果产生有希望的影响。

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