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首页> 外文期刊>Journal of Krishna Institute of Medical Sciences University. >To Study the Activity of Paraoxonase-1 and High-Density Lipoprotein-cholesterol in Alcoholic Liver Cirrhosis
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To Study the Activity of Paraoxonase-1 and High-Density Lipoprotein-cholesterol in Alcoholic Liver Cirrhosis

机译：研究Paraoxonase-1和高密度脂蛋白胆固醇在酒精性肝硬化中的活性

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Background: Alcoholic liver cirrhosis is the most common complication of ethanol abuse. Alcoholic fatty liver progresses to alcoholic hepatitis, cirrhosis and liver failure. Lipoproteins are synthesized by the liver and secreted into the circulation. Alcoholic liver cirrhosis causes alteration in lipoprotein metabolism producing liver steatosis and necrosis. Paraoxonase-1 (PON-1) is an enzyme synthesized in liver and has an esterase activity towards lipid peroxides and circulates in plasma bound to High-Density Lipoproteins - cholesterol (HDL-c). Aim and Objectives: To determine the activity of PON-1 and levels of HDL-c in alcoholic liver disease and to correlate PON-1 activity with HDL-c. Materials and Methods: A Cross sectional study done in Department of Biochemistry and Department of Medicine, Belagavi Institute of st Medical Sciences, Belagavi, Karnataka, India, from 1 st December 2014 to 31 January 2016 Study included 50 males (age range 25-55 years) with alcoholic liver cirrhosis and 50 healthy male participants (age range 25-55 years). PON-1 activity was estimated using spectrophotometric method by the hydrolysis of phenylacetate. HDL-c level was measured by cholesterol oxidase-peroxidase method. Results: The serum PON-1 activity and levels of HDL-c in patients with alcoholic liver cirrhosis were significantly reduced (p0.001) compared with controls. Conclusion: A significant decrease in PON-1 and HDL-c in alcoholic liver cirrhosis may contribute to the risk of atherosclerosis in alcoholic liver cirrhosis patients.
机译：背景：酒精性肝硬化是滥用酒精最常见的并发症。酒精性脂肪肝发展为酒精性肝炎，肝硬化和肝衰竭。脂蛋白由肝脏合成并分泌到循环系统中。酒精性肝硬化会引起脂蛋白代谢改变，从而导致肝脏脂肪变性和坏死。对氧磷酶-1（PON-1）是在肝脏中合成的酶，对脂质过氧化物具有酯酶活性，并在与高密度脂蛋白胆固醇（HDL-c）结合的血浆中循环。目的和目的：确定酒精性肝病中PON-1的活性和HDL-c的水平，并将PON-1的活性与HDL-c相关联。材料和方法：2014年12月1日至2016年1月31日在印度卡纳塔克邦贝拉格维的贝拉格维st医学科学研究所生物化学和医学系进行的横断面研究，研究对象为50名男性（年龄在25-55岁之间）岁）合并酒精性肝硬化和50名健康男性参与者（年龄在25-55岁之间）。通过分光光度法通过乙酸苯酯的水解来估计PON-1活性。 HDL-c水平通过胆固醇氧化酶-过氧化物酶法测量。结果：与对照组相比，酒精性肝硬化患者的血清PON-1活性和HDL-c水平显着降低（p <0.001）。结论：酒精性肝硬化患者中PON-1和HDL-c的显着降低可能会增加酒精性肝硬化患者的动脉粥样硬化风险。

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