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首页> 外文期刊>Journal of Krishna Institute of Medical Sciences University. >Protein Thiols in Essential Hypertension Patients
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Protein Thiols in Essential Hypertension Patients

机译：原发性高血压患者的蛋白质硫醇

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Background: Essential hypertension is one ofthe most prevalent diseases of the world and isan unequivocal risk factor for cardiovascularmorbidity and mortality. Several previousstudies have shown that increased free radicalactivity is suggested to play an important rolein the lipid peroxidation and protein oxidationof cellular structures causing cell injury and isimplicated in the pathogenesis of vasculardiseaseand essential hypertension is one ofthem. The thiols groups on proteins are knownto play a major role in maintaining theantioxidant status of the body. Aims andObjectives: The current study was designed tofind out the levels of such protein bound thiolsin essential hypertension patients. Materialsand Methods: The study was conducted on 45essential hypertension patients and 25 healthysubjects without any underlying medicaldisorder as controls. Patients were divided intothree groups according to the 2003 EuropeanSociety of Hypertension-European Society ofCardiology (ESH/ ESC) guidelines (grade I, II,III). Serum and urine protein thiols weredetermined by spectrophotometric methodsusing dithionitrobenzoic acid (DTNB) andcorrelated with blood pressure (BP). Results:There was a significant decrease in serumprotein thiols in essential hypertensive patientscompared to healthy controls (p0.01) andcorrelated positively with grade II and grade IIIessential hypertension. In urine samples therewas a significant increase in protein and a decreasein protein bound thiols (p0.01) which alsocorrelated positively with grade II and grade IIIessential hypertension. Conclusions: Proteinbound thiols; the major antioxidants in the bodyare decreased in essential hypertensive patients.Due to increased consumption of protein boundthiols in such oxidative environment, there wasa significant decrease in protein bound thiolsin urine.
机译：背景：原发性高血压是世界上最流行的疾病之一，并且是心血管疾病发病率和死亡率的明确危险因素。先前的一些研究表明，增加的自由基活性被认为在引起细胞损伤的细胞结构的脂质过氧化和蛋白质氧化中起重要作用，并暗示其与血管性疾病的发病有关，而原发性高血压是其中的一种。已知蛋白质上的硫醇基团在维持人体的抗氧化状态中起主要作用。目的和目的：本研究旨在确定与蛋白质结合的硫醇类药物在原发性高血压患者中的水平。材料与方法：本研究针对45位基本高血压患者和25位健康受试者，没有任何潜在的医学障碍作为对照。根据2003年欧洲高血压学会-欧洲心脏病学会（ESH / ESC）指南（I，II，III级）将患者分为三组。用二硫代硝基苯甲酸（DTNB）通过分光光度法测定血清和尿蛋白硫醇，并与血压（BP）相关。结果：与健康对照组相比，原发性高血压患者的血清蛋白硫醇水平显着降低（p <0.01），并且与II级和III级高血压呈正相关。在尿液样本中，蛋白质结合的硫醇含量显着增加，而与蛋白质结合的硫醇含量则降低（p <0.01），这也与II级和III级高血压相关。结论：蛋白结合的硫醇;原发性高血压患者体内的主要抗氧化剂减少。由于在这种氧化环境中蛋白质结合硫醇的消耗增加，尿液中蛋白质结合硫醇的含量显着减少。

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