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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >The alternative complement pathway promotes IgM antibody-dependent and -independent adherence of Bacteroides to polymorphonuclear leukocytes through CR3 and CR1.
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The alternative complement pathway promotes IgM antibody-dependent and -independent adherence of Bacteroides to polymorphonuclear leukocytes through CR3 and CR1.

机译：替代补体途径促进拟杆菌的IgM抗体依赖性和非依赖性粘附通过CR3和CR1与多形核白细胞粘附。

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摘要

Natural immunoglobulin M (IgM) antibodies act synergistically with the alternative complement pathway to promote opsonization and adherence of Bacteroides thetaiotaomicron and Bacteroides fragilis to polymorphonuclear leukocytes (PMNs). This study characterizes the PMN receptors involved in adherence of Bacteroides opsonized by the alternative pathway and determines the effect of natural IgM antibodies on receptor involvement and on the molecular form of C3 deposited on the bacteria. A model system consisting of the six isolated proteins of the alternative pathway with or without supplemental isolated normal IgM was used for opsonization, and results were compared to those obtained with serum. The results demonstrate that the alternative pathway promotes adherence of Bacteroides to PMNs through complement receptors 1 and 3 (CR3), and epitopes in CR3 besides those mediating iC3b binding do not participate. The results also demonstrate that natural IgM antibodies do not influence the character of the ligands or receptors involved in this interaction.
机译：天然免疫球蛋白M（IgM）抗体与替代补体途径协同作用，促进细菌拟杆菌（Theactotaides thetaiotaomicron）和脆弱拟杆菌（Bacteroides fragilis）的调理作用和粘附，使其粘附于多形核白细胞（PMN）。这项研究表征了参与通过替代途径调理的拟杆菌的粘附的PMN受体，并确定了天然IgM抗体对受体参与以及对沉积在细菌上的C3分子形式的影响。使用由交替途径的六个分离的蛋白质组成的模型系统进行或不进行补充分离的正常IgM的调理作用，并将结果与​​用血清获得的结果进行比较。结果表明，该替代途径可通过互补受体1和3（CR3）促进拟杆菌对PMN的粘附，除了介导iC3b结合的那些外，CR3中的表位不参与。结果还证明天然IgM抗体不影响参与该相互作用的配体或受体的特性。

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