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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Class I and class II major histocompatibility molecules play a role in bone marrow-derived macrophage development.
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Class I and class II major histocompatibility molecules play a role in bone marrow-derived macrophage development.

机译:I类和II类主要组织相容性分子在骨髓衍生的巨噬细胞发育中起作用。

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Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We show that MHCI- and MHCII-deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony-stimulating factor type 1 secretion and bone composition. We suggest that MHCI and MHCII molecules play a significant role in macrophage development.
机译:I类和II类主要组织相容性复合体(MHC)分子在T细胞发育和免疫功能中起重要作用。我们显示,MHCI和MHCII缺陷型小鼠的巨噬细胞前体和循环单核细胞数量少,以及异常的骨髓细胞集落刺激因子1型分泌和骨组成。我们建议MHCI和MHCII分子在巨噬细胞发展中发挥重要作用。

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