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首页> 外文期刊>Journal of Krishna Institute of Medical Sciences University. >Oral Ulcer Healing after Treatment with Distilled Liquid Smoke of Coconut Shell on Diabetic Rats.
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Oral Ulcer Healing after Treatment with Distilled Liquid Smoke of Coconut Shell on Diabetic Rats.

机译：椰子壳蒸馏液烟熏治疗糖尿病大鼠后口腔溃疡的愈合。

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Background: Distilled liquid smoke from coconut shell (Cocos nucifera L.) by pyrolysis process with final temperature 4000C and then distilled in 120-1500C. The characteristics of distilled liquid smoke are yellow liquid, with acidity 2.39 and density 1.0643 g/cm3. The major identified compounds arephenol (36.6%), 2- methoxyphenol (guaiacol) (25.2%), furfural (17.8%), 2-methoxy-5-methylphenol (5.2%) and 4-ethyl-2- methoxyphenol (EMP) (3.5%) with 28 other minor constituents by GCMS. Aim and Objectives: Distilled liquid smoke was examined to investigate its potential therapeutic to oral ulcer healing and diabetic condition on the rat. Furthermore, the clinical oral ulcer healing was evaluated based on ulcer size and diabetic was evaluated based on Fasting Blood Glucose (FBG) and body weight changes. Material and Methods: Diabetes was induced by alloxan. Seventy-two hours after injection, the diabetic condition was confirmed with FBG of 200mg/dl, then the labial fornix anterior was injured to induce oral ulcer using round steel blade. Results: The clinical oral ulcer healing was improved after treatment with distillated liquid smoke compared to benzydamine hydrochloride and aquadest sterile for three days (p=0.005) and seven days (p=0.000). Treatment for seven days with distilled liquid smoke showed significant improvement of the body mass changes compared to benzydamine hydrochloride (p=0.008) and aquadest sterile (p=0.002). There was no improvement of FBG after treatment with distilled liquid smoke (p=0.152). Conclusion: Treatment with distilled liquid smoke coconut shell can improved oral ulcer healing and body weight changes, but not FBG changes.
机译：背景：通过热解过程从椰子壳（椰子壳）中蒸馏出的液态烟气最终温度为4000℃，然后在120-1500℃下蒸馏。蒸馏液体烟雾的特征是黄色液体，酸度为2.39，密度为1.0643 g / cm3。鉴定出的主要化合物为苯酚（36.6％），2-甲氧基苯酚（愈创木酚）（25.2％），糠醛（17.8％），2-甲氧基-5-甲基苯酚（5.2％）和4-乙基-2-甲氧基苯酚（EMP）（ 3.5％）和GCMS的其他28个次要成分。目的和目的：检查蒸馏烟液以研究其对大鼠口腔溃疡愈合和糖尿病状况的潜在治疗作用。此外，根据溃疡的大小评估临床口腔溃疡的愈合，并根据空腹血糖（FBG）和体重变化评估糖尿病。材料与方法：糖尿病是由四氧嘧啶引起的。注射72小时后，FBG> 200mg / dl确认为糖尿病患者，然后用圆钢刀损伤唇前穹an，引起口腔溃疡。结果：与盐酸苯乙胺和最适无菌水相比，蒸馏水烟熏治疗3天（p = 0.005）和7天（p = 0.000）后，临床口腔溃疡愈合得到改善。与盐酸苯乙胺（p = 0.008）和最无菌的水（p = 0.002）相比，用蒸馏烟熏液治疗7天显示出体重变化的显着改善。用蒸馏液体烟气处理后，FBG没有改善（p = 0.152）。结论：用蒸馏液体烟熏椰子壳处理可改善口腔溃疡的愈合和体重变化，但不能改善FBG。

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