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首页> 外文期刊>Journal of Korean Neurosurgical Society >Radiosurgery Compared with External Radiation Therapy as a Primary Treatment in Spine Metastasis from Hepatocellular Carcinoma : A Multicenter, Matched-Pair Study
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Radiosurgery Compared with External Radiation Therapy as a Primary Treatment in Spine Metastasis from Hepatocellular Carcinoma : A Multicenter, Matched-Pair Study

机译：放射外科与外部放射治疗作为肝细胞癌脊柱转移的主要治疗方法的比较：多中心配对研究

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Objective The aim of this multicenter, matched-pair study was to compare the outcomes of stereotactic radiosurgery (SRS) and conventional external radiation therapy (RT) when used as a primary treatment in spine metastasis from hepatocellular carcinoma (HCC). Methods From 2005 to 2012, 28 patients underwent SRS as the primary treatment in spine metastasis from HCC. Based on sex, age, number of spine metastasis, Child-Pugh classification, interval from original tumor to spine metastasis, and year of treatment, 28 patients who underwent RT were paired. Outcomes of interest were pain relief, progression free survival, toxicities, and further treatment. Results The perioperative visual analog scale (VAS) decrease was larger in SRS group than in RT group, but the difference was not significant (3.7 vs. 2.8, p =0.13). When pain medication was adjusted, the number of patients with complete (n=6 vs.3) or partial (n=12 vs.13) relief was larger in SRS group than in RT group; however, the difference was not significant ( p =0.83). There was no significant difference in progression free survival ( p =0.48). In SRS group, 32.1% of patients had 1 or more toxicities whereas the percentage in RT group was 63.0%, a significant difference ( p =0.04). Six SRS patients and 7 RT patients received further intervention at the treated segment. Conclusion Clinical and radiological outcome were not significantly different between the two treatments. Toxicities, however, were more prevalent in the RT group. Keywords: Radiosurgery, Radiation therapy, Spine, Metastasis, Hepatocellular carcinoma
机译：目的这项多中心配对研究的目的是比较立体定向放射外科（SRS）和常规外部放射疗法（RT）作为肝细胞癌（HCC）脊柱转移的主要治疗方法的结果。方法2005年至2012年，对28例HCC脊柱转移患者进行了SRS治疗。根据性别，年龄，脊柱转移的数目，Child-Pugh分类，从原始肿瘤到脊柱转移的间隔以及治疗的年份，对28例接受了RT的患者进行了配对。感兴趣的结果是缓解疼痛，无进展生存期，毒性和进一步治疗。结果SRS组围手术期视觉模拟量表（VAS）的下降幅度大于RT组，但差异无统计学意义（3.7 vs. 2.8，p = 0.13）。调整止痛药后，SRS组完全缓解（n = 6 vs.3）或部分缓解（n = 12 vs.13）的患者人数大于RT组。然而，差异不显着（p = 0.83）。无进展生存期无显着差异（p = 0.48）。在SRS组中，有32.1％的患者具有1种或多种毒性，而在RT组中，该比例为63.0％，差异有统计学意义（p = 0.04）。 6例SRS患者和7例RT患者在治疗阶段接受了进一步干预。结论两种治疗方法的临床和影像学结果无显着差异。然而，毒性在RT组中更为普遍。关键词：放射外科，放射治疗，脊柱，转移，肝细胞癌

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