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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Innate immune processes are sufficient for driving silicosis in mice
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Innate immune processes are sufficient for driving silicosis in mice

机译：先天免疫过程足以驱动小鼠矽肺病

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The lung is constantly exposed to potentially pathogenic particles and microorganisms. It has become evident recently that not only innate but also adaptive immune responses to particulates, such as SiO2 entering the respiratory tract, are complex and dynamic events. Although the cellular mechanisms and anatomical consequences involved in the development of silicosis have been studied extensively, they still remain poorly understood. Based on their capacity for immune regulation, lymphocytes may play a key role in the respiratory response to environmental challenge by SiO2. The objective of this study was to characterize the impact of SiO2 exposure on respiratory immune processes, with particular emphasis on evaluating the importance of lymphocytes in the murine silicosis model. Therefore, lymphopenic mice, including NK-deficient, Rag1a?’/a?’, or a combination (Rag1a?’/a?’ NK-depleted), were used and demonstrated that SiO2-induced fibrosis and inflammation can occur independently of T, B, NK T, and NK cells. Studies in Rag1a?’/a?’ mice suggest further that lymphocytes may participate in the regulation of SiO2-induced inflammation through modulation of the Nalp3 inflammasome. This observation may have clinical relevance in the treatment of inflammatory and fibrotic lung diseases that are refractory or respond suboptimally to current therapeutics.
机译：肺不断暴露于潜在的病原体颗粒和微生物。最近已经变得明显的是，不仅是先天的而且对于诸如呼吸道进入的SiO 2的颗粒的适应性免疫应答也是复杂且动态的事件。尽管已广泛研究了矽肺病发展过程中涉及的细胞机制和解剖学后果，但仍知之甚少。基于它们的免疫调节能力，淋巴细胞可能在SiO2对环境挑战的呼吸反应中起关键作用。这项研究的目的是表征SiO2暴露对呼吸道免疫过程的影响，特别强调评估小鼠矽肺模型中淋巴细胞的重要性。因此，使用了包括NK缺陷型，Rag1a？'/ a？'或组合（Rag1a？'/ a？'NK耗竭）的淋巴细胞减少小鼠，并证明了SiO2诱导的纤维化和炎症可以独立于T ，B，NK T和NK细胞。 Rag1a？/ a？'小鼠的研究进一步表明，淋巴细胞可能通过调节Nalp3炎性体参与了SiO2诱导的炎症的调节。该观察结果可能在治疗难治性或对当前治疗方法产生最佳反应的炎性和纤维化肺部疾病中具有临床意义。

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