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首页> 外文期刊>Journal of Korean medical science. >Prescription Pattern of NSAIDs and the Prevalence of NSAID-induced Gastrointestinal Risk Factors of Orthopaedic Patients in Clinical Practice in Korea
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Prescription Pattern of NSAIDs and the Prevalence of NSAID-induced Gastrointestinal Risk Factors of Orthopaedic Patients in Clinical Practice in Korea

机译：在韩国的临床实践中，非甾体抗炎药的处方模式和非甾体抗炎药引起的骨科患者胃肠道危险因素的患病率

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This is a cross-sectional observational study undertaken to explore the current prescription pattern of non-steroidal anti-inflammatory drugs (NSAIDs) and the prevalence of NSAID-induced gastrointestinal (GI) risk factors of orthopaedic patients in real clinical practice in Korea. Study cohort included 3,140 orthopaedic outpatients at 131 hospitals and clinics between January 2008 and August 2008. A self-administered questionnaire was completed by each patient and physician. A simplified risk scoring scale (the Standardized Calculator of Risk for Events; SCORE) was used to measure patients' risk for GI complications. The pattern of NSAIDs prescription was identified from medical recordings. Forty-five percents of the patients belonged to high risk or very high risk groups for GI complications. The cyclooxygenase-2 enzyme (COX-2) selective NSAID showed a propensity to be prescribed more commonly for high/very high GI risk groups, but the rate was still as low as 51%. In conclusion, physician's considerate prescription of NSAIDs with well-understanding of each patient's GI risk factors is strongly encouraged in order to maximize cost effectiveness and to prevent serious GI complications in Korea. Other strategic efforts such as medical association-led education programs and application of Korean electronic SCORE system to hospital order communication system (OCS) should also be accompanied in a way to promote physician's attention.
机译：这是一项横断面观察性研究，旨在探讨韩国目前在非甾体抗炎药（NSAIDs）的处方模式以及骨科患者中NSAID引起的胃肠道（GI）危险因素的普遍性。研究队列包括2008年1月至2008年8月间131家医院和诊所的3140名骨科门诊患者。每位患者和医生均填写了一份自行填写的问卷。使用简化的风险评分量表（事件风险标准计算器; SCORE）来衡量患者发生胃肠道并发症的风险。从医学记录中确定了NSAID处方的模式。百分之四十五的患者属于胃肠道并发症的高风险或极高风险人群。环氧合酶2酶（COX-2）选择性非甾体抗炎药对高/非常高GI风险组显示出更常见的处方倾向，但发病率仍低至51％。总之，强烈建议医师考虑周全的非甾体类抗炎药处方应充分理解每位患者的胃肠道危险因素，以最大程度地提高成本效益并防止韩国发生严重的胃肠道并发症。其他战略上的努力，例如由医学协会主导的教育计划和将韩国电子SCORE系统应用于医院指令通讯系统（OCS），也应以引起医师注意的方式进行。

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