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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias
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Immunologic basis for the rare occurrence of true nonsecretory plasma cell dyscrasias

机译：真正的非分泌性浆细胞分泌异常少见的免疫学基础

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摘要

Lymphocytes and plasma cells are major actors of the adaptive immune response and can rightly be considered as human health keepers. However, recombination and mutation events occurring at high rate in the B cell lineage also expose these cells to gene alterations, potentially resulting in uncontrolled and life-threatening cell proliferation. Although in cultured cell lines, such gene alterations frequently generate nonsecretory variants, most immunoproliferative B cell disorders feature in vivo immunoglobulin (Ig) secretion. In this paper, we review the molecular mechanisms involved in various instances of the rare, nonsecretory myelomas, in light of current notions about the molecular control of Ig production, assembly, and secretion in normal B cells. We finally document the attractive hypothesis that B cell clones, which retain nonsecretable, intracellular Igs, may be ideal, in vivo targets for efficient anti-idiotypic immune responses, and clones featuring an abundant secretion may by contrast easily induce T cell anergy and escape the anti-tumoral immune surveillance.
机译：淋巴细胞和浆细胞是适应性免疫反应的主要参与者，可以正确地视为人类健康的守护者。但是，在B细胞谱系中发生率很高的重组和突变事件也使这些细胞暴露于基因改变，从而可能导致不受控制的威胁生命的细胞增殖。尽管在培养的细胞系中，此类基因改变经常会产生非分泌性变异，但大多数免疫增生性B细胞疾病均以体内免疫球蛋白（Ig）分泌为特征。在本文中，我们根据有关正常B细胞​​中Ig产生，组装和分泌的分子控制的当前观念，回顾了罕见，非分泌性骨髓瘤的各种情况涉及的分子机制。我们最后记录了一个有吸引力的假设，即保留不可分泌的细胞内Ig的B细胞克隆可能是有效抗独特型免疫反应的理想体内靶标，而具有大量分泌的克隆则可能容易诱导T细胞无反应性并逃脱抗肿瘤免疫监视。

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