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首页> 外文期刊>Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society >Integrin-mediated inhibition of interleukin-8 secretion from human neutrophils by collagen type I
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Integrin-mediated inhibition of interleukin-8 secretion from human neutrophils by collagen type I

机译：整合素介导的I型胶原抑制人嗜中性白细胞分泌白介素8

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摘要

The function of neutrophils in the inflammatory response is modulated by contact with ECM proteins. We have now investigated the effect of collagen type I on secretion of the cytokine IL-8 by human neutrophils in vitro. Collagen type I inhibited the secretion of IL-8 from neutrophils maintained under basal conditions or stimulated with fMLF. This effect was accompanied by down-regulation of IL-8 mRNA, and it appeared to be specific to collagen type I among ECM proteins, in that it was not observed with fibronectin or laminin. The inhibitory effect of collagen type I on IL-8 secretion was dependent on collagen concentration and cell density. It was also abolished in the presence of antibodies to integrin ?±2?21 but was not affected by antibodies to integrin ?±5?21 or ?24. Our results thus suggest that collagen type I inhibits the secretion of IL-8 by human neutrophils in a selective manner and that this effect is mediated by the interaction of collagen with integrin ?±2?21.
机译：中性粒细胞在炎症反应中的功能是通过与ECM蛋白接触来调节的。现在我们已经研究了I型胶原对人嗜中性粒细胞在体外分泌细胞因子IL-8的影响。 I型胶原蛋白可抑制基础条件下维持或由fMLF刺激的嗜中性白细胞分泌IL-8。这种作用伴随着IL-8 mRNA的下调，并且它似乎对ECM蛋白中的I型胶原具有特异性，因为在纤连蛋白或层粘连蛋白中未观察到。 I型胶原对IL-8分泌的抑制作用取决于胶原浓度和细胞密度。在存在针对整联蛋白α±2β21的抗体的情况下也将其消除，但是不受针对整联蛋白α±5β21或β24的抗体的影响。因此，我们的结果表明I型胶原以选择性的方式抑制人嗜中性白细胞的IL-8分泌，并且这种作用是由胶原与整联蛋白α±2β21的相互作用介导的。

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