The immunophenotype of mast cells and its utility in the diagnostic work‐up of systemic mastocytosis

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The immunophenotype of mast cells and its utility in the diagnostic work‐up of systemic mastocytosis

机译：肥大细胞的免疫表型及其在系统性肥大细胞增多症诊断中的作用

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SMcomprisesaheterogeneousgroupofdisorders,characterizedbyanabnormalaccumulationofclonalMCsin1ormoretissues,frequentlyinvolvingtheskinandBM.Despitethefactthatmostadultpatients(90%)carrythesamegeneticlesion(D816VKITmutation),thediseasepresentswithmultiplevariantswithverydistinctclinicalandbiologicfeatures,adiverseprognosis,anddifferenttherapeuticrequirements.RecentadvancesinthestandardizationofthestudyofBMMCbyMFCallowedreproducibleidentificationandcharacterizationofnormal/reactiveMCsandtheirprecursors,aswellastheestablishmentofthenormalMCmaturationalprofiles.Analysisoflargegroupsofpatientsversusnormal/reactivesampleshashighlightedtheexistenceofaberrantMCphenotypesinSM,whichareessentialforthediagnosisofthedisease.Inturn,3clearlydistinctandalteredmaturation‐associatedimmunophenotypicprofileshavebeenreportedrecentlyinSM,whichprovidecriteriaforthedistinctionbetweenISMpatientswithMC‐restrictedandmultilineageKITmutation;thus,immunphenotypingalsocontributestoprognosticstratificationofISM,particularlywhenanalysisoftheKITmutationonhighlypurifiedBMcellsisnotroutinelyavailableinthediagnosticwork‐upofthedisease...

机译：SMcomprisesaheterogeneousgroupofdisorders，characterizedbyanabnormalaccumulationofclonalMCsin1ormoretissues，frequentlyinvolvingtheskinandBM.Despitethefactthatmostadultpatients（> 90％）carrythesamegeneticlesion（D816VKITmutation），thediseasepresentswithmultiplevariantswithverydistinctclinicalandbiologicfeatures，adiverseprognosis，anddifferenttherapeuticrequirements.RecentadvancesinthestandardizationofthestudyofBMMCbyMFCallowedreproducibleidentificationandcharacterizationofnormal / reactiveMCsandtheirprecursors，aswellastheestablishmentofthenormalMCmaturationalprofiles.Analysisoflargegroupsofpatientsversusnormal / reactivesampleshashighlightedtheexistenceofaberrantMCphenotypesinSM，whichareessentialforthediagnosisofthedisease.Inturn，3clearlydistinctandalteredmaturation-associatedimmunophenotypicprofileshavebeenreportedrecentlyinSM，whichprovidecriteriaforthedistinctionbetweenISMpatientswithMC-restrictedandmultilineageKITmutation;因此，immunphenotypingalsocontributestoprognosticstratificationofISM，杂色当无法对高纯度BM细胞进行KIT突变分析时，通常无法在该疾病的诊断工作中使用...

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2015年第1期|共11页
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1. The immunophenotype of mast cells and its utility in the diagnostic work-up of systemic mastocytosis [J] . Teodosio Cristina, Mayado Andrea, Sanchez-Munoz Laura, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2015,第1期

机译：肥大细胞的免疫表型及其在系统性肥大细胞增多症诊断中的作用
2. Immunophenotyping of mast cells: a sensitive and specific diagnostic tool for systemic mastocytosis [J] . P.L.A. van Daele, B.S. Beukenkamp, W.M.C. Geertsma Kleinekoort, The Netherlands journal of medicine. . 2009,第4期

机译：肥大细胞免疫分型：系统性肥大细胞增多症的灵敏和特异性诊断工具
3. Evolution of urticaria pigmentosa into indolent systemic mastocytosis: abnormal immunophenotype of mast cells without evidence of c-kit mutation ASP-816-VAL. [J] . Noack F, Escribano L, Sotlar K, Leukemia and lymphoma . 2003,第2期

机译：色素性荨麻疹演变为惰性的全身性肥大细胞增多症：肥大细胞的免疫表型异常，没有c-kit突变ASP-816-VAL的证据。
4. Anti-IgE Treatment Overcomes Intolerability of Honeybee- Venom Ultra-Rush Immunotherapy in Indolent Systemic Mastocytosis [C] . B. Wedi, D. Wieczorek, U. Raap, Collegium Internationale Allergologicum . 2007

机译：抗IgE治疗克服了蜜腺超鼠疫免疫疗法在惰性全身乳细胞诱变中的不耐受性
5. FATE OF BONE MARROW-DERIVED CULTURED MAST CELLS AFTER INTRACUT ANEOUS, INTRAPERITONEAL,AND INTRAVENOUS TRANSFER INTO GENETICALLY MAST CELL-DEFICIENT W/Wv MICE Evidence that Cultured Mast Cells Can Give Rise to Both Connective Tissue Type and Mucosal Mast [D] . 仲野, 徹 1988

机译：骨内源性，腹膜内和静脉内转移到遗传上缺乏乳腺的W / Wv小鼠后，骨髓来源的肥大细胞的命运证据表明，培养的肥大细胞可以使结缔组织类型和粘膜肥大同时上升
6. Correspondence: The classification of systemic mastocytosis should include mast cell leukemia (MCL) and systemic mastocytosis with a clonal hematologic non–mast cell lineage disease (SM-AHNMD) [O] . Peter Valent, Michel Arock, Cem Akin, -1

机译：对应：全身性肥大细胞增多症的分类应包括肥大细胞白血病（MCL）和全身性肥大细胞增多症以及克隆性血液学非肥大细胞系疾病（SM-AHNMD）
7. The immunophenotype of mast cells and its utility in the diagnostic work-up of systemic mastocytosis [O] . Teodosio, Cristina, Mayado, Andrea, Sánchez-Muñoz, Laura, 2016

机译：肥大细胞的免疫表型及其在系统性肥大细胞增多症诊断中的作用

The immunophenotype of mast cells and its utility in the diagnostic work‐up of systemic mastocytosis

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