Emerging single‐cell technologies in immunology

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Emerging single‐cell technologies in immunology

机译：新兴的单细胞免疫学技术

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Duringevolution,theimmunesystemhasdiversifiedtoprotectthehostfromtheextremelywidearrayofpossiblepathogens.Untilrecently,immuneresponsesweredissectedbyuseofglobalapproachesandbulktools,averagingresponsesacrosssamplesandpotentiallymissingparticularcontributionsofindividualcells.Thisisastronglylimitingfactor,consideringthatinitialimmuneresponsesarelikelytobetriggeredbyarestrictednumberofcellsatthevanguardofhostdefenses.Thedevelopmentofnovel,single‐celltechnologiesisamajorinnovationofferinggreatpromiseforbasicandtranslationalimmunologywiththepotentialtoovercomesomeofthelimitationsoftraditionalresearchtools,suchaspolychromaticflowcytometryormicroscopy‐basedmethods.Atthetranscriptionallevel,muchprogresshasbeenmadeinthefieldsofmicrofluidicsandsingle‐cellRNAsequencing.Attheproteinlevel,masscytometryalreadyallowstheanalysisoftwiceasmanyparametersasflowcytometry.Inthisreview,weexplorethebasisandoutcomeofimmune‐celldiversity,howgeneticallyidenticalcellsbecomefunctionallydifferent,andtheconsequencesfortheexplorationofhost‐immunedefenseresponses.Wewillhighlighttheadvantages,trade‐offs,andpotentialpitfallsofemerging,single‐cell‐basedtechnologiesandhowtheyprovideunprecedenteddetailofimmuneresponses...

机译：Duringevolution，theimmunesystemhasdiversifiedtoprotectthehostfromtheextremelywidearrayofpossiblepathogens.Untilrecently，immuneresponsesweredissectedbyuseofglobalapproachesandbulktools，averagingresponsesacrosssamplesandpotentiallymissingparticularcontributionsofindividualcells.Thisisastronglylimitingfactor，consideringthatinitialimmuneresponsesarelikelytobetriggeredbyarestrictednumberofcellsatthevanguardofhostdefenses.Thedevelopmentofnovel，单celltechnologiesisamajorinnovationofferinggreatpromiseforbasicandtranslationalimmunologywiththepotentialtoovercomesomeofthelimitationsoftraditionalresearchtools，suchaspolychromaticflowcytometryormicroscopy-basedmethods.Atthetranscriptionallevel，muchprogresshasbeenmadeinthefieldsofmicrofluidicsandsingle-cellRNAsequencing.Attheproteinlevel，masscytometryalreadyallowstheanalysisoftwiceasmanyparametersasflowcytometry.Inthisreview，weexplorethebasisandoutcomeofimmune-celldiversity，howgeneticallyidenticalcellsbecomefunctionallydifferent，andtheconsequenc用于探索宿主免疫防御反应。我们将突出优势，权衡和潜在的陷阱，以单细胞技术以及如何提供前所未有的免疫应答详细信息...

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2015年第1期|共10页
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机译：无细胞免疫：构建和体外表达编码单链抗体库的基于PCR的文库
2. Emerging single-cell technologies in immunology [J] . Herderschee Jacobus, Fenwick Craig, Pantaleo Giuseppe, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2015,第1期

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Emerging single‐cell technologies in immunology

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