CD4+/CD8+ double‐positive T cells: more than just a developmental stage?

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CD4+/CD8+ double‐positive T cells: more than just a developmental stage?

机译：CD4 + / CD8 +双阳性T细胞：不仅仅是发展阶段？

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CD4+/CD8+DPthymocytesareawell‐describedTcelldevelopmentalstagewithinthethymus.However,oncedifferentiated,theCD4+lineageortheCD8+lineageisgenerallyconsideredtobefixed.Nevertheless,matureCD4+/CD8+DPTcellshavebeendescribedinthebloodandperipherallymphoidtissuesofnumerousspecies,aswellasinnumerousdiseasesettings,includingcancer.TheexpressionofCD4andCD8isregulatedbyaverystricttranscriptionalprograminvolvingthetranscriptionfactorsRunx3andThPOK.InitiallythoughttobemutuallyexclusivewithinCD4+andCD8+Tcells,CD4+/CD8+Tcellpopulations,outsideofthethymus,haverecentlybeendescribedtoexpressconcurrentlyThPOKandRunx3.ConsiderableheterogeneityexistswithintheCD4+/CD8+DPTcellpool,andthefunctionofCD4+/CD8+Tcellpopulationsremainscontroversial,withconflictingreportsdescribingcytotoxicorsuppressiverolesforthesecells.Inthisreview,wedescribehowtranscriptionalregulation,lineageoforigin,heterogeneityofCD4andCD8expression,age,species,andspecificdiseasesettingsinfluencethefunctionalityofthisrarelystudiedTcellpopulation...

机译：CD4 + / CD8 + DPthymocytesareawell-describedTcelldevelopmentalstagewithinthethymus.However，oncedifferentiated，theCD4 + lineageortheCD8 + lineageisgenerallyconsideredtobefixed.Nevertheless，matureCD4 + / CD8 + DPTcellshavebeendescribedinthebloodandperipherallymphoidtissuesofnumerousspecies，aswellasinnumerousdiseasesettings，includingcancer.TheexpressionofCD4andCD8isregulatedbyaverystricttranscriptionalprograminvolvingthetranscriptionfactorsRunx3andThPOK.InitiallythoughttobemutuallyexclusivewithinCD4 + andCD8 + T细胞，CD4 + / CD8 + Tcellpopulations，outsideofthethymus，haverecentlybeendescribedtoexpressconcurrentlyThPOKandRunx3.ConsiderableheterogeneityexistswithintheCD4 + / CD8 + DPT细胞池和CD4 + / CD8 + T细胞群的功能仍存在争议，与描述这些细胞的细胞毒性或抑制性的报告有争议。离子...

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《Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society》 |2015年第1期|共8页
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中图分类人体生理学;
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1. Changes in CD4+, CD8+, CD4+ CD8+, and Immunoglobulin M-Positive Peripheral Blood Mononuclear Cells of Postweaning Multisystemic Wasting Syndrome-Affected Pigs and Age-Matched Uninfected Wasted and Healthy Pigs Correlate with Lesions and Porcine Circovirus Type 2 Load in Lymphoid Tissues [J] . Laila Darwich, Joaquim Segalés, Mariano Domingo, Clinical and diagnostic laboratory immunology . 2002,第2期

机译：断奶后多系统衰竭综合症感染的猪和年龄匹配的未感染的废弃健康猪的CD4 +，CD8 +，CD4 +，CD8 +和免疫球蛋白M阳性外周血单个核细胞的变化与淋巴组织中病变和猪圆环病毒2型负荷相关
2. Changes in CD4+, CD8+, CD4+ CD8+, and Immunoglobulin M-Positive Peripheral Blood Mononuclear Cells of Postweaning Multisystemic Wasting Syndrome-Affected Pigs and Age-Matched Uninfected Wasted and Healthy Pigs Correlate with Lesions and Porcine Circovirus Type 2 Load in Lymphoid Tissues [J] . Laila Darwich, Joaquim Segalés, Mariano Domingo, Clinical and diagnostic laboratory immunology . 2002,第2期

机译：断奶后多系统衰竭综合症感染的猪和年龄匹配的未感染的废弃健康猪的CD4 +，CD8 +，CD4 +，CD8 +和免疫球蛋白M阳性外周血单个核细胞的变化与淋巴组织中病变和猪圆环病毒2型负荷相关
3. Differential expression of PKCα and PKCβ isozymes in CD4+, CD8+ and CD4+/CD8+ double positive human T cells [J] . Debreacute, Patrice, Kouml, FEBS Letters . 1994,第3期

机译：PKCα和PKCβ同工酶在CD4 +，CD8 +和CD4 + / CD8 +双阳性人T细胞中的差异表达
4. IMMUNIZATION OF DENDRITIC CELLS PULSED WITH PRRS VIRUS GP5 PROTEIN INDUCES CD4+ BUT NOT CD8+ T CELLS [C] . Nguyen-Dinh Quat, Jeongran Min, Jiwon Han, Congress ofthe International Pig Veterinary Society . 2008

机译：用PRRS病毒GP5蛋白脉冲树突细胞的免疫诱导CD4 +但不是CD8 + T细胞
5. Provision of antigen-specific CD4+ T cells prevents the tolerization of CD8+ tumor-specific T cells in a mouse model of prostate cancer. [D] . Shafer-Weaver, Kimberly Ann. 2009

机译：提供抗原特异性CD4 + T细胞可防止在前列腺癌的小鼠模型中耐受CD8 +肿瘤特异性T细胞。
6. Thymocytes can become mature T cells without passing through the CD4+ CD8+ double-positive stage [O] . 1996

机译：胸腺细胞可以成为成熟的T细胞而无需经过CD4 + CD8 +的双重阳性阶段
7. Changes in CD4+, CD8+, CD4+ CD8+, and Immunoglobulin M-Positive Peripheral Blood Mononuclear Cells of Postweaning Multisystemic Wasting Syndrome-Affected Pigs and Age-Matched Uninfected Wasted and Healthy Pigs Correlate with Lesions and Porcine Circovirus Type 2 Load in Lymphoid Tissues [O] . Darwich, Laila, Segalés, Joaquim, Domingo, Mariano, 2002

机译：断奶后多系统衰竭综合症感染的猪和年龄匹配的未感染的废弃健康猪的CD4 +，CD8 +，CD4 +，CD8 +和免疫球蛋白M阳性外周血单个核细胞的变化与淋巴组织中病变和猪圆环病毒2型负荷相关

CD4+/CD8+ double‐positive T cells: more than just a developmental stage?

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