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首页> 外文期刊>Journal of Medical Biochemistry >Determining the Need for Repeat Testing of Blood Ethanol Concentration: Evaluation of the Synchron Blood Ethyl Alcohol Assay Kit
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Determining the Need for Repeat Testing of Blood Ethanol Concentration: Evaluation of the Synchron Blood Ethyl Alcohol Assay Kit

机译：确定需要重复测试血液乙醇浓度：同步血液乙醇测定试剂盒的评估

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Summary Background In clinical laboratories, a common practice used to verify tests prior to reporting is repeat testing. Our objective was to evaluate the differences between the results of blood ethanol concentration (BEC) test repetitions and report on the role of repeat testing to prevent reporting of incorrect results. Methods We conducted a retrospective study of data retrieved from the Bursa Yuksek Ihtisas Training and Research Hospital’s document management system by calculating the percentage change between repeated BEC test runs. To assess for clinical relevance, the bias between two results from the same sample was compared using the 1988 Clinical Laboratory Improvement Amendments’ (CLIA) proficiency testing allowable total error (TEa) limits. Results From a total of 1,627 BEC tests performed between January 2017 and January 2018, 70% (1,133) were repeat tested. Of these, 830 resulted in BECs between 0–5 mmol/L, of which 237 (28.5%) were above the 25% acceptable TEa. Two hundred seventy-six BEC test results were greater than &14 mmol/L, and there was a good consensus between the initial and repeat test results (99%). In this group, the mean bias was 0.0% (95%, CI = -9.8–9.8%). However, three of the repeat test results were considered significantly different. There were two discordant results in the 5–14 mmol/L ethanol level, and the mean bias was 2.1% (95%, CI = -15.0–19.1%). Conclusion The majority of the repeated BEC test values were the same as the baseline value; therefore, there may be limited benefit in continuing such frequent repeated analyses.
机译：发明背景在临床实验室中，用于在报告之前验证测试的常见实践是重复测试。我们的目标是评估血液乙醇浓度（BEC）重复测试结果之间的差异，并报告重复测试在防止报告错误结果方面的作用。方法我们通过计算重复的BEC测试运行之间的百分比变化，对从Bursa Yuksek Ihtisas训练研究医院的文档管理系统中检索到的数据进行了回顾性研究。为了评估临床相关性，使用1988临床实验室改进修正案（CLIA）熟练程度测试允许的总误差（TEa）限制比较了同一样品的两个结果之间的偏差。结果2017年1月至2018年1月进行的总共1,627项BEC测试中，有70％（1,133）被重复测试。其中，有830个BEC在0-5 mmol / L之间，其中237个（28.5％）高于25％可接受的TEa。 276个BEC测试结果均大于＆ 14 mmol / L，并且在初始和重复测试结果之间达成了良好的共识（99％）。在该组中，平均偏差为0.0％（95％，CI = -9.8-9.8％）。但是，三个重复测试结果被认为是显着不同的。在5-14 mmol / L的乙醇水平中有两个不一致的结果，平均偏差为2.1％（95％，CI = -15.0-19.1％）。结论大部分重复的BEC测试值与基线值相同。因此，继续进行此类频繁的重复分析可能会产生有限的收益。

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