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首页> 外文期刊>Journal of Medical Biochemistry >THE ROLE OF ADIPOCYTOKINES IN COLON CANCER AND ADENOMAS / ULOGA ADIPOCITOKINA U KANCERU I ADENOMIMA DEBELOG CREVA
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THE ROLE OF ADIPOCYTOKINES IN COLON CANCER AND ADENOMAS / ULOGA ADIPOCITOKINA U KANCERU I ADENOMIMA DEBELOG CREVA

机译：脂联素在结肠癌和腺瘤中的作用/脂联素在结肠癌和腺瘤中的作用

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Metabolic changes resulting from obesity, insulin insensitivity, and imbalances in hormones such as adiponectin, leptin, resistin, apelin and visfatin, which are derived from white adipose tissue-derived hormone, are directly linked to both colon cancer (CC) and inflammatory bowel diseases increasing tissue-derived risk. We conducted this study to evaluate the relationship between the circulating concentrations of adiponectin, leptin, resistin, apelin and visfatin and colon adenoma and CC. Our study included 90 participants aged >18 years who were divided into three groups: colon cancer, adenoma and control. The serum concentrations of the investigated adipohormones were measured with ELISA in 30 patients with colon adenoma, 30 with CC and 30 controls with no colon pathology. Demographic, anthropometric, metabolic and hormonal parameters were also recorded. The group means were compared by using one-way analysis of variance (ANOVA). Dual comparisons between groups were analyzed with the Tukey test. Pearson correlation coefficient was used to determine the relation between continuous variables. Adiponectin and leptin levels in patients with adenomas (p<0.000; p<0.000, respectively) and CC (p<0.000; p<0.000, respectively) were lower than in controls. Apelin level in patients with CC (p<0.000; p<0.000, respectively) was lower than in patients with adenomas and in controls. Resistin and visfatin levels in patients with CC (p<0.000; p<0.000, respectively) were higher than in patients with adenomas and in controls.
机译：肥胖，胰岛素敏感性低下以及源自白色脂肪组织的激素衍生的脂联素，瘦素，抵抗素，阿珀林和维斯汀等激素失衡导致的代谢变化与结肠癌（CC）和炎症性肠病都直接相关增加组织衍生的风险。我们进行了这项研究，以评估脂联素，瘦素，抵抗素，apelin和visfatin循环浓度与结肠腺瘤和CC之间的关系。我们的研究包括90位年龄大于18岁的参与者，他们分为三组：结肠癌，腺瘤和对照组。用ELISA法测定了30例结肠腺瘤患者，30例CC患者和30例无结肠病理的对照者的被测脂肪激素的血清浓度。还记录了人口统计学，人体测量学，代谢和激素参数。使用单向方差分析（ANOVA）比较组均值。使用Tukey检验分析组之间的双重比较。皮尔逊相关系数用于确定连续变量之间的关系。腺瘤（分别为p <0.000; p <0.000）和CC（分别为p <0.000; p <0.000）的患者的脂联素和瘦素水平低于对照组。 CC患者的Apelin水平（分别为p <0.000; p <0.000）低于腺瘤患者和对照组。 CC患者的抵抗素和visfatin水平（分别为p <0.000; p <0.000）高于腺瘤患者和对照组。

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