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首页> 外文期刊>Journal of Medical Biochemistry >THE PREVALENCE OF PAI-1 4G/5G POLYMORPHISM IN WOMEN WITH FETAL LOSS – FIRST DATA FOR A SERBIAN POPULATION / U?ESTALOST POLIMORFIZMA PAI-1 4G/5G KOD ?ENA SA SPONTANIM POBA?AJEM - PRVI PODACI ZA SRPSKU POPULACIJU
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THE PREVALENCE OF PAI-1 4G/5G POLYMORPHISM IN WOMEN WITH FETAL LOSS – FIRST DATA FOR A SERBIAN POPULATION / U?ESTALOST POLIMORFIZMA PAI-1 4G/5G KOD ?ENA SA SPONTANIM POBA?AJEM - PRVI PODACI ZA SRPSKU POPULACIJU

机译：胎儿丢失的女性中PAI-1 4G / 5G多态性的患病率-塞尔维亚人的原始数据/ ESTALOST POLIMORFIZMA PAI-1 4G / 5G KOD？

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Background: Plasminogen activator inhibitor 1 (PAI-1) is an inhibitor of fibrinolysis. The PAI-1 4G/5G polymorphism is associated with elevated plasma levels of PAI-1. Over- expression of PAI-1 and impaired fibrinolysis in homozygous carriers of the 4G/4G PAI polymorphism may lead to abnor- mal placental formation and increased risk of fetal loss (FL). The aim of our study was to determine the frequency of this polymorphism in patients with FL in a Serbian population. Methods: The study was carried out in a group of 203 women (91 controls and 112 women with FL). The presence of PAI-1 4G/5G polymorphism was detected by PCR-RFLP analysis. Results: Slightly increased frequency of the PAI-1 4G/4G genotype was observed in the study group compared to the controls (32.1% vs. 30.8%). The frequency of PAI-1 was highest in women experiencing FL in the second trimester of pregnancy (50%), but this difference was not statistically sig- nificant. Conclusions: Our findings suggest that PAI-1 4G/4G might be a risk factor for FL occurring in the second trimester of pregnancy. Further studies are required in order to determine the role of PAI-1 4G/5G polymorphism in the etiology of FL.
机译：背景：纤溶酶原激活物抑制剂1（PAI-1）是纤维蛋白溶解抑制剂。 PAI-1 4G / 5G多态性与PAI-1血浆水平升高有关。 4G / 4G PAI多态性纯合子携带者中PAI-1的过度表达和纤溶作用受损可能会导致胎盘形成异常并增加胎儿丢失（FL）的风险。我们研究的目的是确定塞尔维亚人群中FL患者这种多态性的频率。方法：本研究在203名女性（91名对照组和112名患有FL的女性）中进行。通过PCR-RFLP分析检测到PAI-1 4G / 5G多态性的存在。结果：与对照组相比，在研究组中观察到PAI-1 4G / 4G基因型的频率略有增加（32.1％对30.8％）。 PAI-1的频率在妊娠中期的FL患者中最高（50％），但这一差异在统计学上无统计学意义。结论：我们的发现表明，PAI-1 4G / 4G可能是妊娠中期妊娠FL的危险因素。为了确定PAI-1 4G / 5G多态性在FL的病因中的作用，还需要进一步的研究。

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