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首页> 外文期刊>Journal of Medical Biochemistry >Oxidative Stress in Obesity and Metabolic Syndrome in Asian Indians
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Oxidative Stress in Obesity and Metabolic Syndrome in Asian Indians

机译：亚洲印第安人肥胖和代谢综合症的氧化应激

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Oxidative Stress in Obesity and Metabolic Syndrome in Asian IndiansOxidative stress is associated with the individual components of metabolic syndrome and has been implicated in the development of complications of these metabolic disorders. In this study oxidative stress levels have been compared in obese Indians (a high-risk population for diabetes and cardiovascular disorders) with and without metabolic syndrome. 30 adult normotensive, normoglycemic obese subjects and 35 adults with metabolic syndrome of either sex with BMI >23 kg/m2 were compared with 30 adult, healthy volunteers with BMI 2. Anthropometric parameters, blood pressure, biochemical parameters, hydroperoxides levels and total antioxidant capacity were estimated. The obese groups with and without metabolic syndrome had significantly increased anthropometric parameters like waist circumference and index of central obesity and aqueous phase hydroperoxides when compared with normal controls. The metabolic syndrome group also had significantly increased blood sugar levels, lipid profile and hydroperoxide levels when compared to obese or control groups. There was no alteration in the total antioxidant capacity in any of the groups. The Triglyceride/HDL-Cholesterol ratio (>3), a surrogate marker of insulin resistance, indicates insulin resistance in the metabolic syndrome group. The anthropometric profile, insulin resistance and oxidative stress seen in obesity are further elaborated in metabolic syndrome. Thus, the early identification of high-risk individuals based on anthropometric parameters, lipid profile, insulin resistance and indices of oxidative stress may help to prevent the development of complications of metabolic syndrome.
机译：肥胖和亚洲印第安人代谢综合征中的氧化应激氧化应激与代谢综合征的各个组成部分相关，并已与这些代谢性疾病并发症的发生有关。在这项研究中，比较了患有和不患有代谢综合征的肥胖印度人（糖尿病和心血管疾病的高危人群）的氧化应激水平。将30名成年人的血压正常，血糖正常的肥胖者和35名患有BMI> 23 kg / m2的性别的代谢综合征的成年人与30名BMI 2的健康成年人进行了比较。被估计。与正常对照组相比，患有和不患有代谢综合征的肥胖人群的人体测量学参数都有显着提高，例如腰围和中部肥胖指数以及水相过氧化氢指数。与肥胖或对照组相比，代谢综合征组的血糖水平，脂质分布和氢过氧化物水平也显着增加。在所有组中，总抗氧化剂能力均未改变。甘油三酸酯/ HDL-胆固醇比率（> 3）是胰岛素抵抗的替代标志，表明代谢综合征组的胰岛素抵抗。在肥胖症中观察到的人体测量学特征，胰岛素抵抗和氧化应激在代谢综合征中得到进一步阐述。因此，根据人体测量学参数，脂质分布，胰岛素抵抗和氧化应激指数及早识别高危个体可能有助于预防代谢综合征并发症的发展。

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