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首页> 外文期刊>Journal of Medical Biochemistry >Morphofunctional Characteristics of Pituitary Adrenocorticotropes in An Animal Model of Heat Stress
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Morphofunctional Characteristics of Pituitary Adrenocorticotropes in An Animal Model of Heat Stress

机译：垂体肾上腺皮质激素在热应激动物模型中的形态功能特征

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Morphofunctional Characteristics of Pituitary Adrenocorticotropes in An Animal Model of Heat StressAs a result of the global warming, the average ambient temperature during summertime has increased in regions with moderate continental cli mate. The effects of 24 h exposure to heat stress (35±1 °C) on the morphology and function of pituitary adrenocorticotropes were examined in adult male Wistar rats. Significant changes in the morphofunctional features of adrenocorticotropes were found after the heat stress, with no differences noted in the cell shape or localization, compared to controls. The adrenocorticotropes cell volume, as well as the volume density, were significantly decreased (p<0.05) by 12.3% and 26.7%, respectively, in comparison with controls. The concentration of plasma adrenocorticotropic hormone and serum corticosterone in the heat stressed group were significantly decreased (p<0.05) by 21.9% and 27.2%, respectively, compared to controls. These findings suggest that 24 h exposure of adult male rats to heat stress has an inhibitory effect on the morphofunctional characteristics of adrenocorticotropes.
机译：在热应激动物模型中垂体促肾上腺皮质激素的形态功能特征由于全球变暖，在大陆气候中等的地区，夏季的平均环境温度有所升高。研究了成年雄性Wistar大鼠24小时暴露于热应激（35±1°C）对垂体促肾上腺皮质激素的形态和功能的影响。在热应激后，发现肾上腺皮质激素的形态功能特征发生了显着变化，与对照组相比，在细胞形状或位置上没有发现差异。与对照组相比，促肾上腺皮质激素的细胞体积以及体积密度分别显着降低（p <0.05）12.3％和26.7％。与对照组相比，热应激组的血浆促肾上腺皮质激素和血清皮质酮浓度分别显着降低（p <0.05）21.9％和27.2％。这些发现表明成年雄性大鼠暴露于热应激24小时对肾上腺皮质激素的形态功能特征具有抑制作用。

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