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首页> 外文期刊>Journal of Medical Biochemistry >The Importance of Determining Human Placental Lactogen in the Third Trimester of Pregnancy
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The Importance of Determining Human Placental Lactogen in the Third Trimester of Pregnancy

机译：在妊娠中期确定人胎盘乳原的重要性

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The Importance of Determining Human Placental Lactogen in the Third Trimester of PregnancyHuman placental lactogen (HPL) is a hormone produced by the placenta with a role in the regulation of fetoplacental growth. In this paper, the results of HPL determination in the third trimester of pregnancy are presented with the aim of testing the sensitivity of this biochemical marker for detecting placental dysfunction, fetal vitality and risk of bad outcome. The tests were performed on 370 women with high-risk pregnancy, between the 20th and 36th week of pregnancy. HPL was determined by an ELISA method using Bioserv Diagnostics tests and the results were read by a STAT-FAX 303+ reader. When compared to normal pregnancy, a significant decrease in the level of HPL biomarker was identified in preeclampsia (p<0.01), whereas in diabetes the serum level of HPL was significantly higher (p<0.01). A significant positive correlation between the level of HPL during pregnancy and the weight of a newborn child, its head circumference and Apgar score was obtained. The results of the research indicate that the maternal concentration of the HPL biomarker is directly connected to the vitality of placental tissue, so that HPL in the third trimester of pregnancy can be used as an indicator of placental insufficiency and fetal vitality.
机译：在妊娠晚期确定人胎盘乳原的重要性人胎盘乳原（HPL）是胎盘产生的一种激素，在调节胎盘的生长中起作用。本文介绍了妊娠晚期的HPL测定结果，目的是测试该生化标记物检测胎盘功能障碍，胎儿活力和不良结局风险的敏感性。在怀孕第20周至第36周之间，对370位高危妊娠妇女进行了测试。 HPL通过ELISA方法使用Bioserv Diagnostics测试确定，结果通过STAT-FAX 303+读取器读取。与正常妊娠相比，先兆子痫中HPL生物标志物的水平明显降低（p <0.01），而在糖尿病中，HPL的血清水平显着更高（p <0.01）。妊娠期间HPL水平与新生儿体重，其头围和Apgar得分之间存在显着正相关。研究结果表明，HPL生物标志物的母体浓度与胎盘组织的活力直接相关，因此妊娠晚期的HPL可作为胎盘功能不全和胎儿活力的指标。

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