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首页> 外文期刊>Journal of Medical Biochemistry >Determining the Relationship Between Homocysteinemia and Biomarkers of Inflammation, Oxidative Stress and Functional Kidney Status in Patients with Diabetic Nephropathy
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Determining the Relationship Between Homocysteinemia and Biomarkers of Inflammation, Oxidative Stress and Functional Kidney Status in Patients with Diabetic Nephropathy

机译：确定高半胱氨酸血症与糖尿病肾病患者炎症，氧化应激和功能性肾脏状态的生物标志物之间的关系

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SummaryBackground: One of the leading causes of terminal renal failure is diabetic nephropathy. The aim of this study was to determine the relationship between homocysteine levels and the biomarkers of renal function, inflammation and oxidative stress, as well as the incidence of macrovascular complications in patients with diabetic nephropathy.Methods: Sixty-four patients with diabetic nephropathy were included in this study. They were divided according to their homocysteine levels into two groups: hyperhomocysteinemic (HHcy, n=47) and normohomocysteinemic patients (NHCy, n=17). The re sults were compared to a control group (n=20) with normal renal function and without diabetes. Besides homocysteine, cystatine C, creatinine, urea, albuminuria, creatinine clearance, lipid status parameters, apolipoprotein A-I and B, lipo protein (a), CRP, fibrinogen, oxidative LDL were determined using appropriate methods. The incidence of macro vascular diabetic complications was also determined.Results: The results indicate that the level of renal dysfunction is greater in HHcy than in NHcy patients (p0.05), and in patients with macroalbuminuria compared to patients with microalbuminuria (65% vs. 39%, p<0.05).Conclusions: It can be concluded that HHcy is significantly present in patients with diabetic nephropathy, especially if there is greater reduction of renal function. Besides that, significantly higher concentrations of inflammatory (fibrinogen) and oxidative stress (oxLDL) markers were present in HHcy patients with diabetic nephropathy compared to NHcy patients.Therefore in diabetic nephropathy patients it is useful to regularly monitor the levels of homocysteine, as well as inflammatory and markers of oxidative stress.
机译：摘要背景：终末性肾衰竭的主要原因之一是糖尿病肾病。这项研究的目的是确定同型半胱氨酸水平与糖尿病肾病患者肾功能，炎症和氧化应激以及大血管并发症发生率的生物标志物之间的关系。方法：纳入了64例糖尿病肾病患者。在这个研究中。根据其同型半胱氨酸水平将其分为两组：高同型半胱氨酸血症（HHcy，n = 47）和正常同型半胱氨酸血症（NHCy，n = 17）。将结果与肾功能正常且无糖尿病的对照组（n = 20）进行比较。除了高半胱氨酸，半胱氨酸蛋白酶C，肌酐，尿素，蛋白尿，肌酐清除率，脂质状态参数，载脂蛋白A-1和B，脂蛋白（a），CRP，纤维蛋白原，氧化性LDL均采用适当的方法测定。结果：结果表明，HHcy患者的肾功能不全水平高于NHcy患者（p0.05），而巨蛋白尿患者比微蛋白尿患者（65％） vs. 39％，p <0.05）。结论：可以得出结论，HHcy在糖尿病肾病患者中明显存在，尤其是在肾功能降低更大的情况下。除此之外，与NHcy患者相比，HHcy糖尿病肾病患者的炎症（纤维蛋白原）和氧化应激（oxLDL）标记物的浓度显着更高，因此在糖尿病肾病患者中定期监测同型半胱氨酸和高半胱氨酸的水平非常有用。炎症和氧化应激的标志物。

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