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首页> 外文期刊>Journal of Medical Sciences >Evaluation of Ethocel? Premium Ethylcellulose Ether Derivatives with Different Molecular Weights as Controlled-release Matrix Forming Functional Polymers for Ibuprofen
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Evaluation of Ethocel? Premium Ethylcellulose Ether Derivatives with Different Molecular Weights as Controlled-release Matrix Forming Functional Polymers for Ibuprofen

机译：评估Ethocel ？ 具有不同分子量的高级乙基纤维素醚衍生物作为布洛芬的控释基质形成功能聚合物

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This research work was promoted by the desire to investigate and compare the potentials of conventional granular Ethocel? Premium and Ethocel? Standard FP Premium (the latest in the ethylcellulose ether family) as controlled-release (CR) hydrophobic matrix forming functional polymers for ibuprofen (IBF), a sparingly water-soluble, anti-inflammatory agent. IBF- Ethocel? CR matrix tablets were prepared by direct compression as well as by wet granulation methods. The influence of several parameters such as polymer type, molecular weight (viscosity grade), and particle size; drug-to-polymer (D:P) ratio; and preparation methodology of the matrices on the physical characteristics of the granulations as well as the tablets and IBF release rates from the matrix tablets were investigated. The dissolution equivalency of the release profiles from the formulations investigation were determined making the use of f2-metric technique by fitting the release profiles data into the f2-metric equation using a computer program. Granular Ethocel? polymers with lower viscosity grades demonstrated greater compressibility and lower release rates than those with higher viscosity grades. Ethocel? standard FP Premium polymers exhibited greater efficiency in controlling the release of IBF from the matrices as compared to the granular conventional Ethocel? polymers. Moreover, polymer level and particle size, rather than viscosity grade of the polymers, were found to be determining factors in controlling the drug release rates. Furthermore, matrices prepared by wet granulation showed more efficient control to retard the drug release rates than those prepared by direct compression method.
机译：希望研究和比较常规粒状Ethocel ？的潜力促进了这项研究工作。 Premium和Ethocel ？ Standard FP Premium（乙基纤维素醚家族中的最新产品）是控释（CR）疏水性基质，形成布洛芬（IBF）（一种微水溶性，消炎剂）的功能性聚合物。 IBF- Ethocel ？ CR基质片可直接压片或湿法制粒制备。几个参数的影响，例如聚合物类型，分子量（粘度等级）和粒径;药物与聚合物（D：P）的比例;研究了基质的制备方法，颗粒的物理特性以及片剂和IBF从基质片剂中的释放速率。通过使用f 2 度量技术，通过将释放曲线数据拟合到f 2 度量方程，确定制剂研究释放曲线的溶出当量计算机程序。粒状Ethocel ？ 较低粘度等级的聚合物比较高粘度等级的聚合物具有更高的可压缩性和较低的释放速率。 Ethocel ？ 标准FP Premium聚合物与常规的粒状Ethocel ？相比，在控制IBF从基质释放方面显示出更高的效率。 聚合物。此外，发现聚合物水平和粒度而不是聚合物的粘度等级是控制药物释放速率的决定性因素。此外，通过湿法制粒制备的基质比通过直接压片法制备的基质显示出更有效的控制以延迟药物释放速率。

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