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首页> 外文期刊>Journal of Medical Sciences >Spatially Separated Distribution and Highly Flexible Expression of Adhesion Molecules Facilitates Dynamic Hematopoiesis
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Spatially Separated Distribution and Highly Flexible Expression of Adhesion Molecules Facilitates Dynamic Hematopoiesis

机译：黏附分子的空间分离分布和高度灵活的表达促进动态造血

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In bone marrow niches, direct interactions of Hematopoetic Stem Cells (HSCs) with supportive stromal cells and the extracellular matrix are essential for regulation of hematopoiesis. These interactions are mediated by several sets of adhesion molecules. In vivo , different adhesion molecules were spatially separated and showed specific distributions for the different adhesion molecules. These patterns for VLA-2, VLA-3, ALCAM, VLA-1, VLA-4, VCAM-1 and ICAM-3, varied in size, ranging from a single cell to smaller or larger cell clusters. ICAM-1 and VLA-5 were expressed by virtually all cells. The results are similar in seven individual steady state bone marrows. In vitro , adhesion molecule expression changed for several stromal cell types by exposing them to different inductors as present in different animal sera. Besides the normal blood cell turn over recruitment of more blood cell developmental centers is needed during increased demands for hematopoietic cells. During infection far more granulocytes are demanded by the organism than during normal turnover. Such adaptation to changing conditions is easily accomplished by highly flexible spatio-temporal distribution of adhesion molecules since it provides bone marrow stromal cells with the capacity to deliver the specific lineages that the organism demands.
机译：在骨髓生态位中，造血干细胞（HSC）与支持性基质细胞和细胞外基质的直接相互作用对于调节造血作用至关重要。这些相互作用是由几组粘附分子介导的。在体内，不同的粘附分子在空间上是分开的，并且对于不同的粘附分子显示出特定的分布。 VLA-2，VLA-3，ALCAM，VLA-1，VLA-4，VCAM-1和ICAM-3的这些模式大小不同，范围从单个单元到较小或较大的单元簇。几乎所有细胞都表达ICAM-1和VLA-5。在七个单独的稳态骨髓中，结果相似。在体外，粘附分子的表达通过将几种基质细胞暴露于不同动物血清中的不同诱导物而改变。除正常血细胞外，在对造血细胞的需求增加期间，还需要募集更多的血细胞发育中心。在感染期间，生物体所需的粒细胞比正常周转期间要多得多。通过使粘附分子具有高度灵活的时空分布，可以轻松地实现对变化条件的适应，因为它为骨髓基质细胞提供了传递生物体所需特定谱系的能力。

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