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首页> 外文期刊>Journal of Medical Sciences >Synergistic Effects of Phytochemicals and Oxacillin on Laboratory Passage-Derived Vancomycin-Intermediate Staphylococcus aureus Strain
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Synergistic Effects of Phytochemicals and Oxacillin on Laboratory Passage-Derived Vancomycin-Intermediate Staphylococcus aureus Strain

机译：植物化学物质和奥沙西林对实验室传代的万古霉素-中间金黄色葡萄球菌菌株的协同作用

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摘要

The synergistic effects of 23 selected phytochemicals (10 phenolic acids, 8 flavonoids and 5 alkaloids) in combination with oxacillin against laboratory passage-derived Vancomycin-intermediate Staphylococcus aureus (VISA) strain were investigated. Minimum Inhibitory Concentration (MIC) values of each of the phytochemicals and oxacillin were determined. Fractional Inhibitory Concentration (FIC) index of each combinations were evaluated using the checkerboard broth microdilution assay. Out of 23 phyto-oxacillin combinations, 14 (60.87%) were synergistic and 9 (39.13%) were additive. Flavonoid-oxacillin combination showed 87.5% synergism whereas alkaloid-oxacillin and phenolic acid-oxacillin, respectively exhibited 60 and 40% synergism. The range of FIC index values for synergistic interaction was between 0.0417-0.1333. The synergistic interaction between all the phytochemicals and oxacillin combinations demonstrated reduction in MIC value of oxacillin from 30 to 1.5 μg μL-1 except for quercetin, which markedly reduced the MIC value of oxacillin to 0.5 μg μL-1. Quercetin-oxacillin combination also displayed the lowest FIC index value of 0.0417. In conclusion, these findings suggested that flavonoid-based combination regimens may be useful candidate for treatment options of VISA infections.
机译：研究了23种选定的植物化学物质（10种酚酸，8种黄酮类化合物和5种生物碱）与奥沙西林对实验室传代的万古霉素-中间金黄色葡萄球菌（VISA）菌株的协同作用。确定每种植物化学物质和奥沙西林的最小抑菌浓度（MIC）值。使用棋盘肉汤微稀释测定法评估每种组合的分数抑制浓度（FIC）指数。在23种植物-奥沙西林组合中，有14种（60.87％）具有协同作用，有9种（39.13％）具有累加作用。类黄酮-奥沙西林组合显示出87.5％的协同作用，而生物碱-奥沙西林和酚酸-奥沙西林分别显示出60％和40％的协同作用。协同相互作用的FIC指数值范围在0.0417-0.1333之间。所有植物化学物质和奥沙西林组合之间的协同相互作用表明，除槲皮素外，奥沙西林的MIC值从30μgμL -1 降低到了0.5％，而奥沙西林的MIC值显着降低至0.5μgμL > -1 。槲皮素-奥沙西林组合还显示出最低的FIC指数值0.0417。总之，这些发现表明，基于类黄酮的联合治疗方案可能是治疗VISA感染的有用选择。

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