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首页> 外文期刊>Journal of Medical Cases >Marchiafava-Bignami Disease: A Less Known Neurological Complication of Alcoholism
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Marchiafava-Bignami Disease: A Less Known Neurological Complication of Alcoholism

机译：Marchiafava-Bignami疾病：酒精中毒的鲜为人知的神经系统并发症

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Marchiafava-Bignami disease (MBD) is a disorder associated with chronic alcohol consumption and characterized by demyelination and necrosis of the corpus callosum. Patients may have reduced consciousness, psychotic symptoms, apathy, hemiparesis, ataxia and coma. Although some cases of recovery have been reported, the outcome is poor, with disability or dead. We reported a case of a 56-year-old woman with chronic alcoholism admitted to our hospital with impaired consciousness and a history of gait disturbance. On examination, she was in a coma, with increased muscle tone and left arm paresis. Laboratory studies showed a folic acid deficiency and the CT scan was normal. Magnetic resonance imaging revealed lesions in periventricular white matter and the entire corpus callosum with restriction of water diffusion consistent with the diagnosis of MBD. Despite treatment with B vitamin complex, the patient died. Coma and radiological involvement of the entire corpus callosum are compatible with type A MBD and associated with poor prognosis. Although being a rare alcoholism complication, it should not be forgotten since an early diagnosis and prompt supportive therapy may enable a better outcome.J Med Cases. 2016;7(5):171-173doi: http://dx.doi.org/10.14740/jmc2477w
机译：Marchiafava-Bignami病（MBD）是一种与长期饮酒有关的疾病，其特征在于call体脱髓鞘和坏死。患者的意识，精神症状，冷漠，偏瘫，共济失调和昏迷可能会减轻。尽管已经报道了一些康复病例，但结果差，有残疾或死亡。我们报道了一例56岁的慢性酒精中毒患者，该患者因意识障碍和步态障碍而入院。经检查，她处于昏迷状态，肌肉张力增强，左臂轻瘫。实验室研究表明叶酸缺乏，CT扫描正常。磁共振成像显示脑室周围白质和整个体有病变，水扩散受限，与MBD的诊断一致。尽管使用维生素B复合物治疗，该患者仍死亡。整个体的昏迷和影像学检查与A型MBD相容，并且预后不良。尽管这是一种罕见的酒精中毒并发症，但不应忘记它，因为早期诊断和迅速的支持治疗可能会带来更好的结果。 2016; 7（5）：171-173doi：http://dx.doi.org/10.14740/jmc2477w

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