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首页> 外文期刊>Journal of Medical Cases >Thymoma 20 Years After Hodgkin’s Lymphoma Radiation Therapy: A Case Study
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Thymoma 20 Years After Hodgkin’s Lymphoma Radiation Therapy: A Case Study

机译：霍奇金淋巴瘤放疗后20年胸腺瘤的病例研究

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We present a case of a 48-year-old female who, over the course of 2 years, developed a recurrence of thymoma. She presented in 2013 with nausea and scalp pruritis, which progressed to generalized body pruritis. Examination was normal except for erythroderma noted on both arms and trunk sparing the lower limbs. A CT scan was performed which showed a 2.5 cm anterior mediastinal lymph node mass. A biopsy was performed which indicated a stage 2b thymoma. Her previous medical history was significant for a 1A nodular lymphocyte predominant Hodgkin’s lymphoma in 1992 for which she received mantle field radiation. Her presenting symptoms were thought to be of paraneoplastic origin. Thymectomy and excision of the pleural seeding occurred in 2013 with good results. A year later, a follow-up PET scan revealed a recurrence of her thymoma. Chemotherapy was started with good regression; however, in 2015 the thymoma had spread to the lungs, adjacent pleura and pericardium. Second line chemotherapy was initiated. This case report highlights the possible association between mantle field radiation for Hodgkin’s lymphoma leading to a future thymoma. It emphasizes the need to consider secondary malignancies in the differential diagnosis for patients presenting with unexplained symptoms and a previous history of radiation therapy.J Med Cases. 2016;7(4):153-154doi: http://dx.doi.org/10.14740/jmc2466w
机译：我们介绍了一例48岁女性，该女性在2年的时间内出现了胸腺瘤复发。她在2013年出现恶心和头皮瘙痒症，并发展为全身性全身性瘙痒症。除手臂和躯干保留下肢的红皮病外，检查正常。进行CT扫描显示前纵隔淋巴结肿大2.5厘米。进行的活检表明为2b期胸腺瘤。她先前的病史对1992年以霍奇金氏淋巴瘤为主的1A结节性淋巴细胞具有重要意义，并接受了地幔辐射。人们认为她出现的症状是副肿瘤起源。 2013年进行了胸腺切除和胸膜切开术，效果良好。一年后，随访PET扫描发现她的胸腺瘤复发。化疗开始时回归良好;然而，在2015年，胸腺瘤扩散到了肺，邻近的胸膜和心包。开始二线化疗。该病例报告强调了霍奇金淋巴瘤的地幔辐射与导致未来胸腺瘤的可能联系。它强调需要对出现无法解释的症状和已有放射治疗史的患者进行鉴别诊断时考虑继发性恶性肿瘤。 2016; 7（4）：153-154doi：http://dx.doi.org/10.14740/jmc2466w

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