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首页> 外文期刊>Journal of Medical Sciences >S (+) Ketamine Suppresses TNF-α, IL-6 and IL-8 Production in Blood in Major Abdominal Surgery under Combined Epidural-General Anesthesia
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S (+) Ketamine Suppresses TNF-α, IL-6 and IL-8 Production in Blood in Major Abdominal Surgery under Combined Epidural-General Anesthesia

机译：S（+）氯胺酮抑制硬膜外全麻联合大腹部手术血液中TNF-α，IL-6和IL-8的产生

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It has been demonstrated that proinflammatory cytokines such as (TNF-?±), interleukin (IL) 6 and IL-8 increase in patients with trauma, surgical trauma, sepsis burn 40 patients scheduled for major abdominal surgery under combined epidural general anesthesia in gynecologic Department in Kasr El-Aini Hospital were included in this study, patients age was ranged between 18-50 years, patients were ASA I and II. The patients were divided into 2 groups each group 20 patients, group 1 was received S (+) ketamine as a single preincision dose, while in II S (+) ketamine was received preincision and as a repeated doses, S (+) ketamine was injected as a single IV dose 0.5 mg kg-1 before incision in both groups and repeated 0.2 mg kg-1 doses at 20 min interval until 30 min before the end of the operation (In group 2, 20 patients only). This study reported that S (+) ketamine suppressed TNF-?± production IL-6, IL-8. The study also reported that a single S (+) ketamine preincision dose decreased IL-6 to 550?±20 at 30 min before end of operation while the repeated 20 min doses decreased IL-6 to 440?±20 min. IL-8 when single dose of S (+) ketamine was given decreased to 850?±50 at 30 min before the operation, while after repeated S (+) ketamine it was 600?±40 at 30 min before operation end, about TNF-?±. It decreased to reach 1110?±180 in a single dose of S (+) ketamine while it decreased to 1000?±120 in repeated dose of S (+) ketamine. The total dose of S (+) ketamine was 35?±30 in single dose group, while it was 80?±40 in repeated dose group, the dose of ropivacaine given epidurally was 148?±20 in single group while it was 130?±15 in repeated group. The conclusion of the study was S (+) ketamine directly suppresses proinflammatory cytokines production when given in repeated doses; it also decreased the ropivacaine dose needed more in repeated doses of S (+) ketamine.
机译：业已证实，在创伤，手术创伤，败血症烧伤患者中，促发炎性细胞因子（TNF-α±），白介素（IL）6和IL-8升高，计划在妇科联合硬膜外全麻下进行大腹部手术的40例患者这项研究包括了Kasr El-Aini医院的科室，患者年龄在18-50岁之间，患者为ASA I和II。将患者分为2组，每组20名患者，第1组以单次切开前剂量接受S（+）氯胺酮，而在IIS（+）氯胺酮中预先给药，并以重复剂量使用S（+）氯胺酮。两组均在切开之前以0.5 mg kg -1 的单次IV剂量注射，并在20分钟间隔内重复0.2 mg kg -1 剂量，直至结束前30分钟手术（第2组，仅20位患者）。该研究报道S（+）氯胺酮抑制TNF-α产生IL-6，IL-8。该研究还报告说，在手术结束前30分钟，单次S（+）氯胺酮预切口剂量可将IL-6降至550？±20，而重复20分钟剂量可将IL-6降至440？±20分钟。术前30分钟给予单剂量S（+）氯胺酮的IL-8降至850？±50，而重复S（+）氯胺酮术后30分钟的IL-8为600？±40，约为TNF -？±。单剂量的S（+）氯胺酮使它降低至1110±180，而重复剂量的S（+）氯胺酮则降低至1000±±120。单剂量组氯胺酮的总剂量为35？±30，重复剂量组的总剂量为80？±40，硬膜外给予罗哌卡因的剂量为148？±20，剂量为130？±20。重复组±15。该研究的结论是，当重复给药时，S（+）氯胺酮可直接抑制促炎细胞因子的产生。它也减少了重复剂量的S（+）氯胺酮所需要的罗哌卡因剂量。

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