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首页> 外文期刊>Journal of Medical Sciences >Alteration of Serum Levels of Interlukin 1 and Tumor Necrosis Factor in Depression Independentof Treatment or Overdose of Tricyclic Antidepressants
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Alteration of Serum Levels of Interlukin 1 and Tumor Necrosis Factor in Depression Independentof Treatment or Overdose of Tricyclic Antidepressants

机译：抑郁症患者血清白细胞介素1和肿瘤坏死因子的水平变化与三环类抗抑郁药的治疗或用药无关

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The aim of this study was to evaluate the status of serum IL-1b and TNF-?± in depressed patients who treated or non-treated or poisoned with tricyclic antidepressants (TCAs) in comparison to healthy subjects. In this prospective comparative study, patients were selected from those admitted at Loghman-Hakim Hospital from August 2007 to January 2008. Serum level of IL-1b and TNF-?± were compared among group of subjects (10 in each) of healthy subjects, TCA-poisoned patients, TCA-treated depressed patients and non-treated depressed patients. Demographic and clinical data were collected by a questioner filled out by a trained practitioner in daily clinical management. Blood was tested for liver function, blood cells, electrocardiography and arterial blood gases. Complete blood analysis and demographic data did now show significant change between groups. IL-1b level was higher among females. The group of depressed patients non-treated with TCAs showed higher serum levels of IL-1b and TNF-?± than other groups. No significant difference was observed in IL-1b and TNF-?± values among healthy control, depressed TCA-treated and TCA-poisoned groups. It is concluded that depression and gender may influence the production of cytokines while neither TCAs treatment nor its overdose affect IL-1b and TNF-?±.
机译：这项研究的目的是评估与健康受试者相比，治疗或未治疗或中毒三环类抗抑郁药（TCA）的抑郁症患者血清IL-1b和TNF-α±的状况。在这项前瞻性比较研究中，患者选自2007年8月至2008年1月在Loghman-Hakim医院接受治疗的患者。在健康受试者的受试者（每组10人）中比较了血清IL-1b和TNF-α±， TCA中毒患者，TCA治疗的抑郁症患者和未治疗的抑郁症患者。人口统计学和临床​​数据由提问者收集，该提问者由受过训练的从业人员在日常临床管理中填写。测试了血液的肝功能，血细胞，心电图和动脉血气。现在，全血分析和人口统计学数据确实显示了两组之间的显着变化。女性中IL-1b水平较高。未接受TCA治疗的抑郁症患者的血清IL-1b和TNF-α±水平高于其他人群。在健康对照组，抑郁的TCA治疗组和TCA中毒组之间，IL-1b和TNF-α±值均无显着差异。结论是，抑郁和性别可能会影响细胞因子的产生，而TCAs治疗及其过量都不会影响IL-1b和TNF-α±。

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