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首页> 外文期刊>Journal of Medical Biochemistry >High Molecular Weight Adiponectin Levels are Neither Influenced by Adiponectin Polymorphisms Nor Associated with Insulin Resistance in Mixed-ancestry Hyperglycemic Subjects from South Africa
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High Molecular Weight Adiponectin Levels are Neither Influenced by Adiponectin Polymorphisms Nor Associated with Insulin Resistance in Mixed-ancestry Hyperglycemic Subjects from South Africa

机译：高分子量脂联素水平既不受脂联素多态性的影响，也与来自南非的混合血统高血糖患者的胰岛素抵抗无关

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Summary Background High molecular weight (HMW) adiponectin has antiatherogenic, antiinflammatory and antidiabetic properties and these effects have been linked to its effect on high density lipoprotein cholesterol (HDL-c). Single nucleotide polymorphisms (SNPs) in the adiponectin gene influence adiponectin levels. We examined the relationship between HMW-adiponectin levels and cardiometabolic traits in normo- and hyperglycemic mixed ancestry South Africans and correlated these levels to two common polymorphisms. Methods HMW-adiponectin was determined in 101 subjects from the Cape Town Bellville South community-based study on a mixed ancestry population. Comparisons were made between individuals with normo- and hyperglycemia. Two common SNPs, ADIPOQ SNPs rs17300539 and rs266729, known to affect adiponectin levels were also tested for. Levels of HMW-adiponectin were then correlated with cardiometabolic traits in all groups. Results Levels of HMW-adiponectin were not significantly different in the normo- and hyperglycemic groups (median 11.6 vs. 10.5 μg/mL, p=0.3060) and in men and women (8.44 vs. 11.34 μg/mL, p=0.67). ADIPOQ SNPs rs17300539 and rs266729 did not influence levels of HMW-adiponectin. Robust correlation analyses revealed a significant positive correlation between HMW-adiponectin and HDL-c (r=0.45; 95%CI: 0.27–0.59), similarly in normo- and hyperglycemic participants (p > 0.99). This association was substantially attenuated in robust linear regressions adjusted for age, gender and adiposity. Conclusions Adiponectin levels in this population were not determined by the commonest SNPs of the adiponectin gene, were unaffected by glycemic status; but were significantly correlated with HDL-c levels. Previous studies have attributed some of the beneficial effects of adiponectin to its effect on HDL-c.
机译：背景技术高分子量（HMW）脂联素具有抗动脉粥样硬化，抗炎和抗糖尿病的特性，这些作用与其对高密度脂蛋白胆固醇（HDL-c）的作用有关。脂联素基因中的单核苷酸多态性（SNP）影响脂联素水平。我们检查了正常和高血糖混合血统南非人中HMW脂联素水平与心脏代谢特征之间的关系，并将这些水平与两种常见的多态性相关。方法从开普敦南贝尔维尔南部社区的混合血统人群的101名受试者中确定HMW脂联素。在具有正常血糖和高血糖的个体之间进行了比较。还测试了两种常见的SNP，即已知会影响脂联素水平的ADIPOQ SNP rs17300539和rs266729。然后，在所有组中，HMW-脂联素的水平与心脏代谢特征相关。结果正常和高血糖组（中位数11.6对10.5μg/ mL，p = 0.3060）和男女（8.44对11.34μg/ mL，p = 0.67）的HMW脂联素水平无显着差异。 ADIPOQ SNP rs17300539和rs266729不影响HMW脂联素的水平。稳健的相关性分析显示，在正常血糖和高血糖参与者中，HMW脂联素与HDL-c之间呈显着正相关（r = 0.45; 95％CI：0.27–0.59）（p> 0.99）。在针对年龄，性别和肥胖调整的稳健线性回归中，这种关联大大减弱了。结论该人群中的脂联素水平不受脂联素基因最常见的SNPs的影响，不受血糖状况的影响。但与HDL-c水平显着相关。先前的研究已将脂联素的某些有益作用归因于其对HDL-c的作用。

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