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首页> 外文期刊>Journal of medical bacteriology. >Antimicrobial Effect of Nano-Zinc Oxide and Nano-Chitosan Particles in Dental Composite Used in Orthodontics
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Antimicrobial Effect of Nano-Zinc Oxide and Nano-Chitosan Particles in Dental Composite Used in Orthodontics

机译：纳米氧化锌和纳米壳聚糖颗粒对口腔正畸牙科复合材料的抗菌作用

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Background: Incidence of white spots due to demineralization of enamel and gingival problems is an unacceptable result of orthodontic treatment. Plaque accumulation and bacterial biofilm growth are responsible for these phenomena. The resin-based dental composites used as bonding agents in orthodontics play a major role in mentioned problems. As recent researches assert the antimicrobial effects of chitosan (CS) and zinc oxide (ZnO) nanoparticles (NPs), it seems that adding these nanoparticles to the composite can be beneficial in reducing the number and function of microorganisms. The aim of this study was to evaluate the antimicrobial effects of ZnO-NP and CS-NP-containing orthodontic composite.Methods: Antibacterial effectiveness of ZnO-NPs and CS-NPs was assessed in four groups against Streptococcus mutans, Streptococcus sanguis and Lactobacillus acidophilus grown both planktonic and as a biofilm on composites. One group as the unmodified control group and three groups consisting of three different concentrations of ZnO-NPs and CS-NPs mixture: 1%, 5% and 10% (1:1 w/w). 108 CFU/ml microorganism suspensions were provided with spectrophotometer. Biofilm formation was quantified by viable counts. Disc agar diffusion (DAD) test was carried out to determine antimicrobial effects of nanoparticles by measuring the inhibition diameter on brain heart infusion agar plates. Finally,viable counts of microorganisms on days 3, 15 and 30 were collected for the antimicrobial effects of eluted components from composite discs.Results: In biofilm formation test, a reduction in bacterial counts was observed with 10% nanoparticle-containing composites compared with their unmodified counterpart. In the DAD test only 10% nanoparticle-containing specimens showed statistically significant inhibition. The only noticeable datain eluted component test was on day 30 for 10% nanoparticle- containing discs, inhibiting L. acidophilus.Conclusion: It seems that a mixture of ZnO-NPs and CS-NPs has induced an antibacterial activity in resin composite; especially in 10% weight concentrations which was significantly higher than other groups.
机译：背景：由于牙釉质脱盐和牙龈问题而导致的白斑出现是正畸治疗的不可接受结果。斑块积累和细菌生物膜生长是造成这些现象的原因。在正畸中用作粘合剂的树脂基牙科复合材料在上述问题中起着重要作用。由于最近的研究断言了壳聚糖（CS）和氧化锌（ZnO）纳米颗粒（NPs）的抗微生物作用，看来将这些纳米颗粒添加到复合材料中可能有益于减少微生物的数量和功能。本研究的目的是评估含ZnO-NP和CS-NP的正畸复合材料的抗菌作用。方法：评估ZnO-NP和CS-NPs在四组中对变形链球菌，血链球菌和嗜酸乳杆菌的抗菌效果。生长在浮游生物和生物膜上的复合材料。一组作为未修饰的对照组，三组由三种不同浓度的ZnO-NP和CS-NP混合物组成：1％，5％和10％（1：1 w / w）。用分光光度计提供108 CFU / ml微生物悬浮液。生物膜形成通过可行的计数进行定量。进行了圆盘琼脂扩散（DAD）测试，通过测量对脑心浸液琼脂平板的抑制直径来确定纳米颗粒的抗菌作用。最后，在第3、15和30天收集了可行的微生物计数，以观察复合盘中洗脱组分的抗菌作用。结果：在生物膜形成测试中，与含10％纳米颗粒的复合物相比，细菌计数减少了。未修改的对应对象。在DAD测试中，只有10％的纳米颗粒标本显示出统计学上的显着抑制作用。洗脱组分测试中唯一值得注意的数据是在第30天检测出含有10％纳米颗粒的圆盘，从而抑制了嗜酸乳杆菌。结论：似乎ZnO-NP和CS-NP的混合物已诱导了树脂复合材料的抗菌活性。特别是在10％的体重浓度下，明显高于其他组。

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