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首页> 外文期刊>Journal of Medical Case Reports >Leptospirosis presenting in a woman with fulminant hepatic failure from Wilson's disease: a case report
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Leptospirosis presenting in a woman with fulminant hepatic failure from Wilson's disease: a case report

机译：一名妇女因威尔逊病暴发性肝衰竭而出现钩端螺旋体病：一例报告

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Introduction We report an unusual case of Wilson's disease that was revealed by presentation of leptospirosis. The prompt detection of this potentially life-threatening disease highlights the importance of careful investigation. To the best of our knowledge, this is the first reported case of leptospirosis involving the development of fulminant liver failure due to Wilson's disease. Case presentation A 17-year-old Caucasian woman presented with fever, rigors, vomiting and scleral jaundice. Following clinical and laboratory evaluation she was diagnosed with leptospirosis. After remission of this disease her condition inexplicably deteriorated. Further investigations revealed that she had Wilson's disease. Conclusions The unexplained deterioration of hepatic function in a young person in remission from leptospirosis should alert the clinician to the presence of an underlying disorder, such as Wilson's disease, the early detection of which is crucial to the prognosis. The mechanism that initiates the development of Wilson's disease is not fully understood, but it is thought that an intercurrent illness, such as viral infection or drug toxicity, could be implicated. In our case, leptospirosis appeared to precipitate the deterioration of liver function in a patient with Wilson's disease, advancing our knowledge of this association. This original case report could have a broader clinical impact across medicine.
机译：简介我们报告了一例异常的威尔逊氏病，该病通过钩端螺旋体病的表现得以揭示。及时发现这种可能威胁生命的疾病突出了进行仔细调查的重要性。据我们所知，这是首次报告钩端螺旋体病病例，涉及由于威尔逊氏病导致的暴发性肝衰竭。病例介绍一名17岁的白人妇女出现发烧，严峻，呕吐和巩膜性黄疸。经过临床和实验室评估，她被诊断出钩端螺旋体病。该病缓解后，她的病情莫名其妙地恶化了。进一步的调查显示她患有威尔逊氏病。结论钩端螺旋体病缓解后的年轻人无法解释的肝功能恶化应提醒临床医生存在潜在的疾病，例如威尔逊氏病，及早发现对预后至关重要。尚不完全了解引发威尔逊氏病发展的机制，但据认为可能涉及并发疾病，例如病毒感染或药物毒性。在我们的案例中，钩端螺旋体病似乎加剧了威尔逊氏病患者的肝功能恶化，这加深了我们对这种关联的认识。最初的病例报告可能会对整个医学产生更广泛的临床影响。

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