• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Case Reports >Uneventful octreotide LAR therapy throughout three pregnancies, with favorable delivery and anthropometric measures for each newborn: a case report
【24h】

Uneventful octreotide LAR therapy throughout three pregnancies, with favorable delivery and anthropometric measures for each newborn: a case report

机译：在三个妊娠中均进行不消极的奥曲肽LAR治疗，并对每个新生儿进行有利的分娩和人体测量：一例病例报告

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction The safety of octreotide use, in its short-acting preparation, in pregnancy is still unclear. This report provides the first documentation of uneventful octreotide LAR use during three pregnancies in a woman with bronchial carcinoid-associated adrenocorticotropic hormone-dependent Cushing's syndrome. Case presentation A 25-year-old Arabic woman presented to our emergency department with rapid onset of headache, flaring acne and hirsutism, facial puffiness, weight gain and paroxysmal myopathy, and paranoiac thoughts of rape and sexual intimidation. After undergoing surgical removal of a mass by left lower lung lobectomy, her residual lung disease medical therapy failed. Chronic octreotide LAR injections were initiated as indicated by a positive octreoscan. Follow-up revealed a long-lasting positive response to octreotide. Avidity of octreotide to somatostatin receptor sub-type 2 was later confirmed by a positive somatostatin receptor sub-type 2 in the resected tumor specimen. Against our instructions, the patient had three spontaneous pregnancies leading to delivery of three full-term healthy children while her octreotide LAR therapy continued. Conclusion This case adds more data supporting the potential for the safe use of octreotide and the feasibility of octreotide LAR use during pregnancy, making compliance with the patient's preference not to withdraw octreotide therapy as soon as her pregnancy is confirmed a thoughtful option.
机译：引言在孕妇中使用奥曲肽短效制剂的安全性尚不清楚。该报告首次报道了一名患有支气管类癌相关的促肾上腺皮质激素依赖型库欣氏综合征的女性在三胎妊娠期间使用奥曲肽LAR的情况。病例介绍一名25岁的阿拉伯妇女到我们的急诊室就诊，发作迅速，出现头痛，痤疮和多毛症张开，面部浮肿，体重增加和阵发性肌病，以及强奸和性恐吓的偏执狂想法。在通过左下肺叶切除术进行手术切除肿块后，她的残留肺部疾病药物治疗失败。如阳性奥曲肽扫描所示，开始了慢性奥曲肽LAR注射。随访显示对奥曲肽有长期持久的积极反应。后来，在切除的肿瘤标本中，阳性的生长抑素受体亚型2证实了奥曲肽对生长抑素受体亚型2的亲和力。根据我们的指示，患者在继续使用奥曲肽LAR治疗的过程中，有3次自然怀孕，导致3名足月健康儿童分娩。结论该病例增加了更多的数据，支持安全使用奥曲肽的可能性以及在怀孕期间使用奥曲肽LAR的可行性，从而使患者一旦确定怀孕就不要撤回奥曲肽治疗，这符合患者的偏好。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号