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首页> 外文期刊>Journal of Medical Case Reports >Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report
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Malignant neuroleptic syndrome following deep brain stimulation surgery: a case report

机译：深部脑刺激手术后恶性精神病综合症：一例报告

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Background The neuroleptic malignant syndrome is an uncommon but dangerous complication characterized by hyperthermia, autonomic dysfunction, altered mental state, hemodynamic dysregulation, elevated serum creatine kinase, and rigor. It is most often caused by an adverse reaction to anti-psychotic drugs or abrupt discontinuation of neuroleptic or anti-parkinsonian agents. To the best of our knowledge, it has never been reported following the common practice of discontinuation of anti-parkinsonian drugs during the pre-operative preparation for deep brain stimulation surgery for Parkinson's disease. Case presentation We present the first case of neuroleptic malignant syndrome associated with discontinuation of anti-parkinsonian medication prior to deep brain stimulation surgery in a 54-year-old Caucasian man. Conclusion The characteristic neuroleptic malignant syndrome symptoms can be attributed to other, more common causes associated with deep brain stimulation treatment for Parkinson's disease, thus requiring a high index of clinical suspicion to timely establish the correct diagnosis. As more centers become eligible to perform deep brain stimulation, neurologists and neurosurgeons alike should be aware of this potentially fatal complication. Timely activation of the deep brain stimulation system may be important in accelerating the patient's recovery.
机译：背景精神安定性恶性综合征是一种罕见但危险的并发症，其特征是体温过高，植物神经功能紊乱，精神状态改变，血流动力学异常，血清肌酸激酶升高和严峻。它最常见的原因是对抗精神病药产生不良反应或突然停用抗精神病药或抗帕金森氏病药物。据我们所知，在帕金森氏病深部脑刺激手术的术前准备过程中，停用抗帕金森氏药物的常规做法从未被报道过。病例介绍我们介绍了一名54岁的白种人男子在深部脑刺激手术之前停用抗帕金森病药物相关的神经安定性恶性综合症的第一例。结论典型的抗精神病药物恶性综合症症状可归因于与帕金森氏病深层脑刺激治疗相关的其他更常见原因，因此需要较高的临床怀疑指数才能及时建立正确的诊断。随着越来越多的中心有资格进行深部脑刺激，神经科医生和神经外科医生都应意识到这种潜在的致命并发症。及时激活深部脑刺激系统可能对加速患者的康复很重要。

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