Oral Exposure to Silver/Gold Nanoparticles: Status of Rat Lipid Profile, Serum Metabolites and Tissue Morphology

F.A. Sulaiman; M.A. Akanji; H.O.B. Oloyede; A.A. Sulaiman; A. Olatunde; E.B. Joel; T.H. Adewale; H.A. Adeboye; S.O. Idris; A.L. Quadri; R.A. Oyegoke; O.S. Adeyemi

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Oral Exposure to Silver/Gold Nanoparticles: Status of Rat Lipid Profile, Serum Metabolites and Tissue Morphology

机译：口服银/金纳米颗粒的暴露：大鼠脂质谱，血清代谢产物和组织形态的状态

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Study investigated the effect of oral administration of gold-silver nanoparticles on rat biochemical parameters and tissue morphology. Wistar rats weighing approximately 180±7 g were randomly assigned into four groups. Animals in the control group received distilled water once daily for 30 days while, those in the treatment groups were administered 10, 50 and 100 mg kg^?1 b.wt. gold-silver nanoparticles. The rats were sacrificed under slight anesthesia, 24 h after the last treatments. Blood and vital organs including the heart, kidney and liver were collected and prepared for biochemical and histopathological determinations. Exposure to Ag/Au nanoparticles altered the rat serum lipid profile ; lowering the HDL-C while raising the atherogenic index. Exposure of Ag/Au nanoparticles in rats caused significant alteration to the levels of serum albumin, total protein, bilirubin, urea and creatinine. The activities of alanine transaminase, aspartate transaminase and alkaline phosphatase in rat serum and tissues were also significantly altered by Ag/Au nanoparticles exposure. The histopathological examination revealed inflammation and cellular degeneration caused by exposure to the Ag/Au nanoparticles. We show evidence that Ag/Au nanoparticles elevated atherogenic index, as well as caused biochemical and morphological alterations, reminiscent of cellular injury.

机译：研究调查了口服金银纳米颗粒对大鼠生化参数和组织形态的影响。将重约180±7 g的Wistar大鼠随机分为四组。对照组的动物每天接受一次蒸馏水，持续30天，而治疗组的动物则分别给予10、50和100 mg kg ^{？1 b.wt。金银纳米粒子。在最后一次治疗后24小时，在轻微麻醉下处死大鼠。收集血液和重要器官，包括心脏，肾脏和肝脏，并准备进行生化和组织病理学测定。暴露于Ag / Au纳米颗粒改变了大鼠的血脂水平;在提高动脉粥样硬化指数的同时降低HDL-C。大鼠暴露于Ag / Au纳米颗粒后，血清白蛋白，总蛋白，胆红素，尿素和肌酐水平显着改变。 Ag / Au纳米颗粒的暴露也显着改变了大鼠血清和组织中丙氨酸转氨酶，天冬氨酸转氨酶和碱性磷酸酶的活性。组织病理学检查显示由于暴露于Ag / Au纳米颗粒而引起的炎症和细胞变性。我们显示的证据表明，Ag / Au纳米颗粒可提高动脉粥样硬化指数，并引起生化和形态改变，使人联想到细胞损伤。}

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《Journal of Medical Sciences》 |2015年第2期|共9页
作者
F.A. Sulaiman; M.A. Akanji; H.O.B. Oloyede; A.A. Sulaiman; A. Olatunde; E.B. Joel; T.H. Adewale; H.A. Adeboye; S.O. Idris; A.L. Quadri; R.A. Oyegoke; O.S. Adeyemi;
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7. Oral Exposure to Silver/Gold Nanoparticles: Status of Rat Lipid Profile, Serum Metabolites and Tissue Morphology [O] . F.A. Sulaiman, M.A. Akanji, H.O.B. Oloyede, 2015

机译：口服暴露于银/金纳米粒子：大鼠脂质谱的状态，血清代谢物和组织形态

Oral Exposure to Silver/Gold Nanoparticles: Status of Rat Lipid Profile, Serum Metabolites and Tissue Morphology

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