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首页> 外文期刊>Journal of Medical Sciences >Effect of Haemodialysis on Plasma Lipid Peroxidation and Endogenous Non-enzymic Antioxidants in Gorgan (South East of Caspian Sea)
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Effect of Haemodialysis on Plasma Lipid Peroxidation and Endogenous Non-enzymic Antioxidants in Gorgan (South East of Caspian Sea)

机译：血液透析对器官（里海东南部）血浆脂质过氧化和内源性非酶类抗氧化剂的影响

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The aim of this study was to evaluate the effect of haemodialysis on lipid peroxidation (the level of lipid peroxidation expressed as malondialdehyde) and endogenous non-enzymic antioxidants before and after the dialysis and compared with control group. The sampling procedure was a purposive sampling. Twenty two patients with Chronic Renal Failure (CRF) disease who were haemodialysed at 5th Azar hospital of Gorgan Dialysis Center (2005). Twenty two age and sex matched healthy control were recruited for this study. Plasma level of malondialdehyde and uric acid were significantly increased and reduced in the postdialysis group when compared with predialysis and control group, respectively (p<0.001). The plasma level of albumin and total bilirubin were significantly increased in postdialysis group when compared with predialysis group (p<0.001). The increasing level of plasma lipid peroxidation and the significant difference of non-enzymic antioxidants in the haemodialyzed pateints after the process of dialysis, maybe related with the pateint uremia, the quality of consumed water in the dialysis procedure, dialysis membrane and the loss of these antioxidants through membranes and hemoconcenteration of them during the dialysis process and the dialysis process (may increase lipid peroxidation during the dialysis process). These states of affairs may play an important role in progress of cardiovascular abnormality in haemodialyzed pateints. Due to this conditions a review of haemodialysis membrane, the techniques used in the dialysis, the consumption of various oral antioxidant, the elimination of active oxygens from the dialysis surrounding are among the measures which can prevent sudden cardiovascular abnormality in the haemodialysis pateints and ultimately these important factors up- grade the pateints quality of life and prevent sudden silent myocardial infarction.
机译：这项研究的目的是评估透析前后血液透析对脂质过氧化（脂质过氧化水平以丙二醛表示）和内源性非酶类抗氧化剂的作用，并与对照组进行比较。抽样程序是有目的的抽样。在Gorgan透析中心第五阿扎尔医院对22例慢性肾功能衰竭（CRF）患者进行了血液透析（2005年）。这项研究招募了22个年龄和性别相匹配的健康对照。与透析前和对照组相比，透析后组血浆丙二醛和尿酸水平显着升高和降低（p <0.001）。透析后组的血浆白蛋白和总胆红素水平明显高于透析前组（p <0.001）。透析后血液透析的血浆中脂质脂质过氧化水平的升高和非酶类抗氧化剂的显着差异，可能与血浆尿毒症，透析过程中的饮用水水质，透析膜及其损失有关抗氧化剂通过膜和在透析过程中以及透析过程中的血液凝结（可能会增加透析过程中脂质的过氧化作用）。这些情况可能在血液透析患者的心血管异常进展中起重要作用。由于这种情况，对血液透析膜的检查，透析中使用的技术，各种口服抗氧化剂的消耗，从透析周围环境中清除活性氧等都是可以防止血液透析患者突然出现心血管异常的措施，最终可以预防这些疾病。重要因素可提高患者的生活质量，并防止突然的无声心肌梗塞。

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