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首页> 外文期刊>Journal of Medical Sciences >The Relationship Between Oxidative Stress and Membrane ATPase Enzyme Activities in Hypercholesterolemic Rats Supplemented with Vitamin E
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The Relationship Between Oxidative Stress and Membrane ATPase Enzyme Activities in Hypercholesterolemic Rats Supplemented with Vitamin E

机译：维生素E补充高胆固醇血症大鼠氧化应激与膜ATP酶活性的关系。

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To examine the influence of vitamin E on oxidative stress and membrane ATPases. Present study conducted on hypercholesterolemic rats. The animals were divided into four equal groups. The control group was fed with chow pellets for 4.5 months. The other groups received high cholesterol or vitamin E or high cholesterol plus vitamin E. The high cholesterol and high cholesterol plus vitamin E groups showed a significant increase of total cholesterol of plasma, erythrocytes and liver and also an increase in plasma phospholipid and triglyceride levels was observed. But erythrocytes and liver phospholipid levels in high choesterol and high cholesterol plus vitamin E groups remained unchanged. There were no significant differences in plasma, erythrocytes and liver total cholesterol levels between high cholesterol and high cholesterol plus vitamin E groups. The plasma triglyceride level was significantly decreased in the high cholesterol plus vitamin E group in comparison to the high cholesterol group. On the other hand, lipid peroxide levels in the high cholesterol group significantly elevated in comparison with the control group. On the contrary, the high cholesterol plus vitamin E group showed a significant decrease in the lipid peroxide levels of plasma, erythrocytes and liver compared to that of high cholesterol group. The glutathione content was found to be significantly lower than the control group. Following vitamin E supplementation, glutathione content was significantly higher in plasma, erythrocytes and liver. The Na+-K+-ATPase and Ca+2-ATPase activities of erythrocytes and liver in high cholesterol group significantly decreased when compared with controls. On the other hand, high cholesterol plus vitamin E injection to the rats suppressed the reduction of Na+-K+-ATPase and Ca+2-ATPase activities in these tissue membranes. In conclusion, long-term administration of vitamin E may be useful in preserving of membrane asymmetry by suppressing the oxidative stress .
机译：检查维生素E对氧化应激和膜ATPase的影响。目前对高胆固醇血症大鼠进行的研究。将动物分为四个相等的组。对照组喂以中国松饼4.5个月。其他组接受高胆固醇或维生素E或高胆固醇加维生素E。高胆固醇和高胆固醇加维生素E组显示血浆，红细胞和肝脏的总胆固醇显着增加，血浆磷脂和甘油三酸酯水平也升高。观测到的。但是高胆固醇，高胆固醇和维生素E组的红细胞和肝磷脂水平保持不变。高胆固醇和高胆固醇加维生素E组之间的血浆，红细胞和肝脏总胆固醇水平无显着差异。与高胆固醇组相比，高胆固醇加维生素E组的血浆甘油三酸酯水平显着降低。另一方面，与对照组相比，高胆固醇组的脂质过氧化物水平显着升高。相反，高胆固醇加维生素E组与高胆固醇组相比，血浆，红细胞和肝脏的脂质过氧化物水平显着降低。发现谷胱甘肽含量显着低于对照组。补充维生素E后，血浆，红细胞和肝脏中的谷胱甘肽含量明显更高。高胆固醇组红细胞和肝脏的Na + -K + -ATPase和Ca +2 -ATPase活性与对照组相比明显降低。另一方面，高胆固醇加维生素E对大鼠的注射抑制了Na + -K + -ATPase和Ca +2 的减少这些组织膜中的-ATP酶活性。总之，长期服用维生素E可通过抑制氧化应激来维持膜的不对称性。

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