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首页> 外文期刊>Journal of Medical Sciences >Inhibition of Gastric Mucosal Damage by Boric Acid Pretreatment in Rats
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Inhibition of Gastric Mucosal Damage by Boric Acid Pretreatment in Rats

机译：硼酸预处理对大鼠胃黏膜损伤的抑制作用

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Boric acid was evaluated for its potential to protect the gastric mucosa against the injuries caused by 80% ethanol, 25% NaCl, 0.2 M NaOH and indomethacin in male Wistar rats. The effects caused by ethanol on gastric wall mucus, gastric levels of non-protein sulfhydryl groups, protein, nucleic acids and malondialdehyde and histopathological effects were also investigated. Boric acid pretreatment at oral doses of 60, 120 and 240 mg kg-1 body weight provided a dose-dependent protection against the ulcerogenic effects of different necrotising agents used. Treatment of rats with 1 ml of 80% ethanol (gavage) was found to cause depletion of stomach-wall mucus, to lower the concentrations of proteins, nucleic acids and non-protein sulfhydryl groups (NP-SH) in the stomach wall and to cause histopathological lesions, including necrosis, corrosion, congestion and hemorrhage. Boric acid treatment showed a dose-dependent protection against all these effects. In the same manner it affected malondialdehyde concentrations altered by ethanol pretreatment. Boric acid also offered protection against mucosal damage caused by indomethacin. Present findings show that boric acid possesses antiulcerogenic effects. Further studies are required to determine its role in the prophylaxis and or the treatment of gastric ulcer disease.
机译：评估了硼酸在雄性Wistar大鼠中保护胃粘膜免受80％乙醇，25％NaCl，0.2 M NaOH和消炎痛引起的损伤的潜力。还研究了乙醇对胃壁粘液，胃中非蛋白巯基，蛋白质，核酸和丙二醛水平的影响以及组织病理学影响。口服硼酸预处理剂量分别为60、120和240 mg kg - 1 体重，可以剂量依赖性地保护不同的坏死剂产生溃疡。发现用1 ml 80％乙醇（灌胃）处理大鼠可导致胃壁粘液消耗，降低胃壁中蛋白质，核酸和非蛋白质巯基（NP-SH）的浓度，并降低引起组织病理学损害，包括坏死，腐蚀，充血和出血。硼酸处理显示出针对所有这些作用的剂量依赖性保护。以相同的方式，它影响通过乙醇预处理改变的丙二醛浓度。硼酸还可以防止吲哚美辛引起的粘膜损伤。目前的发现表明硼酸具有抗溃疡作用。需要进一步研究以确定其在预防和/或治疗胃溃疡疾病中的作用。

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