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首页> 外文期刊>Journal of Medical Sciences >Gastric Antisecretory and Antiulcer Activity of Boric Acid in Rats
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Gastric Antisecretory and Antiulcer Activity of Boric Acid in Rats

机译：硼酸对大鼠胃的抗分泌和抗溃疡活性

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Anti-ulcerogenic potential of boric acid (BA) was investigated using five models of gastric lesion induced in experimental Wistar rats: (1) HCl/ethanol-induced gastric lesions, (2) Absolute ethanol-induced gastric lesions, (3) Indomethacin-HCl/ethanol-induced gastric lesions, (4) Pylorus ligation-induced gastric lesions and (5) Hypothermic restraint stress-induced gastric lesions. In all the models studied, the antiulcer activity of BA was compared with that of cimetidine (100 mg kg-1 p.o.). In models 1, 2, 3 and 5: ulcer index and mucus production was determined. In pylorus ligated rats ulcer index, mucus production, total volume of gastric juice and gastric acidity level were measured. Administration of BA to the rats by oral route (60-240 mg kg-1) dose-dependently prevented the formation of acute gastric lesions in all five models of ulceration. The dose-dependent reduction of lesion formation was in all cases accompanied by significant increases in gastric mucus production. In pylorus ligated rats, total volume of gastric juice and gastric acidity was significantly decreased as compared to control group, these result similar to that produced by cimetidine. The cytoprotective effect of BA against HCl/ethanol induced ulceration was significantly reversed by prior treatment with a dose (20 mg kg-1 ip) of indomethacin that inhibits prostaglandin biosynthesis. The results of this study demonstrate that BA has both prophylactic and curative effects on various experimentally induced gastric ulcers.
机译：使用五种在Wistar实验性大鼠中诱发的胃部病变模型研究了硼酸（BA）的抗溃疡潜力：（1）HCl /乙醇诱发的胃部病变，（2）乙醇诱发的绝对胃部病变，（3）消炎痛- HCl /乙醇诱导的胃部病变，（4）幽门结扎术引起的胃部病变，以及（5）低温约束应激引起的胃部病变。在所有研究的模型中，将BA与西咪替丁（100 mg kg -1 p.o.）的抗溃疡活性进行了比较。在模型1、2、3和5中：确定溃疡指数和粘液产生。测定幽门结扎大鼠的溃疡指数，粘液产生，胃液总体积和胃酸度。通过口服途径（60-240 mg kg -1 ）对大鼠施用BA可以在所有五个溃疡模型中剂量依赖性地预防急性胃损伤的形成。在所有情况下，损伤形成的剂量依赖性减少伴随着胃粘液产生的显着增加。在幽门结扎的大鼠中，胃液的总体积和胃酸度与对照组相比明显降低，这些结果与西咪替丁产生的结果相似。事先用剂量为20 mg kg -1 ip的吲哚美辛抑制前列腺素的生物合成可明显逆转BA对HCl /乙醇诱导的溃疡的细胞保护作用。这项研究的结果表明，BA对各种实验性胃溃疡均具有预防和治疗作用。

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