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首页> 外文期刊>Journal of Medical Sciences >Associations Between CD4 Cell Counts and Clinical Presentations Among HIV/AIDS Patients in Cameroon
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Associations Between CD4 Cell Counts and Clinical Presentations Among HIV/AIDS Patients in Cameroon

机译：喀麦隆HIV / AIDS患者的CD4细胞计数与临床表现之间的关联

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The present study was aimed at establishing relationships between CD4 cell counts and various clinical presentations commonly associated with HIV/AIDS patients in Cameroon. This study was made up of retrospective and prospective phases, carried out among HIV positive cases seen at the Internal Medicine Service of the University of Yaounde Teaching Hospital. After informed consent, data was collected from participants. This included information on demographic and various clinical signs and symptoms associated with HIV/AIDS as well as CD4 cell count results. The population studied consisted of 556 positive cases, 58% females (323) and 42% males (233). HIV positive status were known among 89.9% of the cases following episodes of ill health while Voluntary Counselling and Testing (VCT) diagnosed HIV only among 5% of them. Cases were grouped into clinical categories as follows: A 14.5%, B 33.2%, C 28.2% and 24.1% were not classified. Clinical signs and symptoms were dominated by anaemia 61%, pneumonia 34.5%, meningitis 9.9%, unexplained fiver 34.4%, loss of weight more than 10%, 30.4%, tiredness 21.2 %, diarrhoea 14.2% and cough 11.1%. In all, 29.6% of the subjects had CD4 cell counts less than 100 cell mm-3, while 43.3% of them had counts below 200 cells mm-3. Statistically significant associations were established between low CD4 cell counts and various pathologies as follows: tuberculosis p<0.01, oral candidosis p<0.02, kaposi`s sarcoma p<0.04, herpes zoster p<0.002 and genital herpes p<0.05. The present study shows that majority of the subjects get to know their HIV status very late, already developing clinical signs and symptoms of AIDS with very low CD4 cell counts. There is need for improvement of early HIV diagnosis strategy through education and voluntary counselling among populations in Africa.
机译：本研究旨在建立CD4细胞计数与喀麦隆通常与HIV / AIDS患者相关的各种临床表现之间的关系。这项研究由回顾性和前瞻性阶段组成，在雅温得大学教学医院内科服务的艾滋病毒阳性病例中进行。在知情同意后，从参与者收集数据。其中包括有关与HIV / AIDS相关的人口统计学和各种临床体征和症状以及CD4细胞计数结果的信息。研究的人口包括556例阳性病例，其中女性占58％（323），男性占42％（233）。在疾病发作后的89.9％的病例中，已知HIV阳性状态，而自愿咨询和检测（VCT）仅在5％的病例中诊断出HIV。将病例分为以下临床类别：未分类A 14.5％，B 33.2％，C 28.2％和24.1％。临床体征和症状主要为贫血61％，肺炎34.5％，脑膜炎9.9％，原因不明的34.4％，体重减轻10％以上，30.4％，疲倦21.2％，腹泻14.2％和咳嗽11.1％。在所有受试者中，有29.6％的受试者的CD4细胞计数小于100个细胞mm -3 ，而其中43.3％的受试者的CD4细胞计数小于200个细胞mm -3 。在低CD4细胞计数与各种病理之间建立了统计学上显着的关联，如下所示：结核病p <0.01，口腔念珠菌病p <0.02，卡波西氏肉瘤p <0.04，带状疱疹p <0.002和生殖器疱疹p <0.05。本研究表明，大多数受试者很晚才知道他们的艾滋病毒状况，他们已经发展出具有非常低CD4细胞计数的艾滋病临床症状和体征。有必要通过非洲人群之间的教育和自愿咨询来改善早期艾滋病毒的诊断策略。

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