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首页> 外文期刊>Journal of Medical Sciences >Asymptomatic Bacteriuria in Patients on Antiretroviral Drug Therapy in Calabar
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Asymptomatic Bacteriuria in Patients on Antiretroviral Drug Therapy in Calabar

机译：卡拉巴尔抗逆转录病毒药物治疗的患者无症状细菌尿

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The prevalence of asymptomatic bacteriuria was carried out on 600 HIV Positive patients on antiretroviral drug therapy and 200 apparently healthy individuals (control subjects) in Calabar, Nigeria to determine the current status of asymptomatic bacteriuria among this category of patients. Urine samples were collected in sterile universal bottles and analyzed using standard laboratory diagnostic techniques and cultured using Lee and Williams technique. CD4 cell counts were also measured. The modified Kirby-Bauer sensitivity testing technique was used for antimicrobial testing of the isolates. Patients on antiretroviral therapy had 25.3% asymptomatic bacteriuria while control subjects had 13%. There was a statistically significant difference between the prevalence of infection in patients on antiretroviral therapy and the control subjects (p = 0.0013). Males had a higher prevalence than female subjects but there was no statistically significant difference between the occurrence of infection by gender (p = 0.66). The commonest urinary pathogens isolated amongst the test subjects were Staphylococcus aureus (87.2%) followed by Escherichia coli (84%) and Candida albicans (80.8%) while Candida albicans (19.2%) was the commonest isolated organism in control subjects followed by E. coli (16%) and S. aureus (12.8%). Subjects with CD4 count of less than 200x109 L-1 showed the highest rate of asymptomatic bacteriuria of 92.3% among the test subjects while CD4 count >600x109 L-1 had the highest rate of asymptomatic bacteriuria (35%) among the control subjects. Most of the isolates from patients on antiretroviral therapy were observed to be moderately or highly resistant to the commonly used antibiotics such as Chloramphenicol, Cotrimoxazole and Streptomycin but sensitive to Ciprofloxacin, Oxfloxacin, Sparfloxacin and Refloxacin. This study has shown that patients on antiretroviral therapy are more prone to asymptomatic bacteriuria than normal healthy individuals and recommend the use of Ciprofloxacin or Refloxacin for the treatment of asymptomatic bacteriuria among this category of patients in our environment.
机译：在尼日利亚卡拉巴尔，对600名接受抗逆转录病毒药物治疗的HIV阳性患者和200名显然健康的个体（对照组）进行了无症状菌尿的患病率调查，以确定此类患者中无症状菌尿的现状。将尿液样品收集在无菌的通用瓶中，并使用标准实验室诊断技术进行分析，并使用Lee和Williams技术进行培养。还测量了CD 4 细胞计数。改良的Kirby-Bauer敏感性测试技术用于分离物的抗菌测试。接受抗逆转录病毒治疗的患者无症状菌尿为25.3％，而对照组为13％。接受抗逆转录病毒治疗的患者与对照组的感染率之间存在统计学差异（p = 0.0013）。男性患病率高于女性，但性别感染发生率之间无统计学差异（p = 0.66）。在测试对象中最常见的泌尿道病原体是金黄色葡萄球菌（87.2％），其次是大肠杆菌（84％）和白色念珠菌（80.8％），而白色念珠菌（19.2％）是对照对象中最常见的分离菌，其次是E。大肠杆菌（16％）和金黄色葡萄球菌（12.8％）。 CD 4 计数小于200x10 9 L -1 的受试者在CD中的无症状菌尿率最高，为92.3％在对照组中， 4 计数> 600x10 9 L -1 的无症状菌尿率最高（35％）。观察到大多数接受抗逆转录病毒治疗的患者分离株对常用的抗生素（如氯霉素，复方新诺明和链霉素）具有中等或高度耐药性，但对环丙沙星，奥沙星，司巴沙星和瑞沙星敏感。这项研究表明，接受抗逆转录病毒疗法治疗的患者比正常健康人更容易出现无症状菌尿，并建议在我们环境中的此类患者中使用环丙沙星或瑞氟沙星治疗无症状菌尿。

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