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首页> 外文期刊>Journal of Medical Sciences >Immunogenicity of Neonatal BCG Vaccination in Children Aged 6 Years in Egypt, Is Booster Dose Needed?
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Immunogenicity of Neonatal BCG Vaccination in Children Aged 6 Years in Egypt, Is Booster Dose Needed?

机译：埃及6岁儿童新生儿BCG疫苗的免疫原性，是否需要加强剂量？

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Presence of BCG scar is used as an indicator of vaccination but its significance is still the subject of controversy. The aim of the study was evaluate the immunogenicity of neonatal BCG vaccination in children age 6 years to detect if a booster dose is necessary or not. Two hundred children, selected from primary schools in Damietta by stratified random sampling, from March to December 2010. They divided into two groups, study group (150) with BCG scar, second group (50) lack BCG scar. A questionnaire including personal data, vaccination, disease and drug intake history was completed. Then BCG scar was checked and measured in mm and PPD test was done. Examination for anemia, jaundice, organomegaly and assessment of nutritional status was done. Male to female ratio of 1.27: 1; no significant difference between both groups as regard anthropometric measurement while there was significant increase in BCG diameter in study in comparison to control group (4.66±1.88 vs. 0.0±0.0 mm, respectively). PPD test results revealed that 182 (91.0%) were non-reactive while 18 (9.0%) were suspicious and there was significant difference between groups. Finally, there was powerful, positive, significant correlation between BCG scar and PPD test results. Conclusion of this study revealed that children at the age of school entry better to receive booster dose of BCG vaccination to lengthen and increase the efficacy of the immunity.
机译：卡介苗疤痕的存在被用作疫苗接种的指标，但其重要性仍是争议的主题。该研究的目的是评估6岁儿童的新生儿BCG疫苗接种的免疫原性，以检测是否需要加强剂量。从2010年3月至12月，通过分层随机抽样从Damietta的小学中选出200名儿童。他们分为两组，研究组（150）有卡介苗瘢痕，第二组（50）没有卡介苗瘢痕。完成了包括个人数据，疫苗接种，疾病和吸毒史的问卷调查。然后检查BCG疤痕并以mm为单位进行测量，并进行PPD测试。进行贫血，黄疸，器官增大检查和营养状况评估。男女比例为1.27：1;人体测量在两组之间没有显着差异，而与对照组相比，研究中的BCG直径显着增加（分别为4.66±1.88 vs. 0.0±0.0 mm）。 PPD测试结果显示，无反应的有182（91.0％），而可疑的有18（9.0％），两组之间存在显着差异。最后，BCG疤痕与PPD测试结果之间存在强有力的，正相关的显着相关性。这项研究的结论表明，入学年龄的儿童最好接受加强剂量的BCG疫苗接种，以延长免疫力并提高免疫效力。

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