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首页> 外文期刊>Journal of Medical Sciences >Imputation Approach for Missing Binary Outcomes in Buprenorphine/Naloxone Treatment for Opioid Dependent
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Imputation Approach for Missing Binary Outcomes in Buprenorphine/Naloxone Treatment for Opioid Dependent

机译：阿片类药物依赖性丁丙诺啡/纳洛酮治疗中二元结果缺失的归因方法

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摘要

The opioids is useful to treat the chronic pain. Recently, the opioid mistreatment increased dramatically. The kidney damage may occur due opioid abuse treatment. The creatinine level can be measured to detect the level of kidney damage. The goal of this study is to know the effective drug to control the creatinine among opioid dependent patients. The dependent prior with Bayesian approach is applied to compare the treatment effect. The secondary data on Buprenorphine (BUP) was considered to compare the two drug treatments, viz. (1) BUP+ Standard Medical Management (SMM) and (2) BUP+Extended Medical Mangament (EMM), in opioid dependent patients. In both drug groups the mean creatinine level was found controlled over the duration of the treatment. No rapid changes of creainine level among the patients are observed. At the end of study it is found that the means of creatinine level are higher in BUP+EMM group. The Bayesian dependent prior is found to offer effective tool for drug treatment effect comparison. The drug treatment effect BUP+EMM is found to be more effective to control the creatinine among the patients.
机译：阿片类药物可用于治疗慢性疼痛。最近，阿片类药物的滥用急剧增加。肾损伤可能由于滥用阿片类药物而发生。可以测量肌酐水平以检测肾脏损害的水平。这项研究的目的是了解在阿片类药物依赖患者中控制肌酐的有效药物。使用贝叶斯方法的先验先验来比较治疗效果。丁丙诺啡（BUP）的二级数据被认为可以比较两种药物治疗。 （1）阿片类药物依赖患者的BUP +标准医疗管理（SMM）和（2）BUP +扩展医疗管理（EMM）。在两个药物组中，均发现肌酐水平在治疗期间受到控制。在患者中没有观察到肌酐水平的快速变化。在研究结束时发现，BUP + EMM组的肌酐水平均值较高。贝叶斯依赖先验被发现为药物治疗效果比较提供了有效的工具。发现药物治疗效果BUP + EMM在患者中更有效地控制肌酐。

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