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首页> 外文期刊>Journal of Medical Sciences >Effects of Various Levels of Oral Doses Dexamethasone (Al-nagma) Abused as Cosmetic by Sudanese Women on Wistar Rats
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Effects of Various Levels of Oral Doses Dexamethasone (Al-nagma) Abused as Cosmetic by Sudanese Women on Wistar Rats

机译：苏丹妇女滥用口服剂量的地塞米松（Al-nagma）化妆品对Wistar大鼠的影响

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Dexamethasone (locally known as Al-Nagma) is used as anti-inflammatory drug for different types of inflammatory diseases. Sudanese women abuse this drug as cosmetic for gaining weight and whiten skin, without care of the side effects. The present study aims to evaluate the toxicity of low (60 μg/kg/day) and high doses (180 μg/kg/day) of Dexamethasone on kidney and liver of Wistar rats and to estimate the effect of abuse in normal individual. The rats were randomly classified into three groups, each group contain six rats. Group one (control) received distilled water. Group two treated with low dose (60 μg/kg/day) and group three treated with high dose (180 μg/kg/day). To achieve the objective of this study, the body weight was measured before and after treatment, sodium, potassium, glycated hemoglobin and other Haematological parameters were also measured. Dexamethasone significantly decreased the body weight of Wistar rats treated with low and high dose (22.8±7.4, 19.9±8.3), respectively compared with control group (32.7±9). In addition, there is a significant difference in sodium and HbA1c levels in both groups treated with the dexamesathone. In contrast potassium significantly decreased in both groups when compared with control group. Also pathological changes in fatal organs demonstrated as lesions in liver and kidneys, fatty cytoplasmic vaculation and necrosis of the hepatocytes, glomerular alteration, packing, dilatation, fatty change and necrosis. This study concluded that, Dexamethasone abuse decreased the body weight, rather than believed by Sudanese women. It causes hyperglycemia and hypertension affecting renal function.
机译：地塞米松（当地称为Al-Nagma）被用作抗炎药，用于各种类型的炎症疾病。苏丹妇女滥用这种药物作为化妆品来增加体重和美白皮肤，而无需担心副作用。本研究旨在评估低剂量（60μg/ kg /天）和高剂量（180μg/ kg /天）地塞米松对Wistar大鼠肾脏和肝脏的毒性，并评估滥用对正常个体的影响。将大鼠随机分为三组，每组六只。第一组（对照组）接受蒸馏水。低剂量（60μg/ kg /天）治疗的第二组和高剂量（180μg/ kg /天）治疗的第三组。为了达到本研究的目的，在治疗之前和之后测量体重，还测量钠，钾，糖化血红蛋白和其他血液学参数。与对照组（32.7±9）相比，地塞米松分别显着降低了低剂量和高剂量（22.8±7.4、19.9±8.3）处理的Wistar大鼠的体重。此外，在用地塞米松治疗的两组中，钠和HbA1c的水平存在显着差异。相反，与对照组相比，两组中的钾均显着降低。致命器官的病理变化还表现为肝脏和肾脏的病变，脂肪细胞质的排空和肝细胞坏死，肾小球改变，堆积，扩张，脂肪改变和坏死。这项研究的结论是，滥用地塞米松可以减轻体重，而不是苏丹妇女所认为的。它引起高血糖和高血压，影响肾功能。

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