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首页> 外文期刊>Journal of Medical Sciences >Seroprevalence of Hepatitis A Antibodies among a Sample of School Children
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Seroprevalence of Hepatitis A Antibodies among a Sample of School Children

机译：在学童样本中甲型肝炎抗体的血清阳性率

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The aim of this study was to estimate the prevalence of IgM anti-HAV in students aged from 6-12 years old in Damietta Governorate and to identify factors associated with the prevalence of this infection. The present study included 1000 children, aged 6-12 years; selected from pediatric outpatient clinic; regardless of their vaccination history. They were selected during the period from September 2012 to September 2014. The following data related to identification and socio-demographic characteristics were documented: The individual gender, age, residence, number of household members, number of rooms, number of people sleeping together in the same room, family income, educational level of parents or guardians, availability of piped water supply, presence of sewage and the existence and number of bathrooms in the house. Then IgG and IgM were estimated. Age ranged from 6 to 12 years with a mean of 8.87±1.95 years; 56.7% of cases were males, 66.4% live in rural areas, 46.5% of cases were of low socioeconomic standard and 24.2% of middle standard; previous vaccination was reported in 2.7% of cases, active infection reported in 1.9% cases and previous (old) infection or vaccination was reported in 86.5% of cases. Finally, ALT cases ranged from 8-65 IU mL-1 with a mean of 12.53±5.40 IU mL-1 and AST ranged from 8-29 with a mean of 12.07±2.56 IU mL-1. Positive cases were younger (7.94±2.09 vs. 8.89±1.94, respectively); of low socioeconomic standards (37.7%), had significantly higher ALT and AST. No case of actively infected group had previous vaccination or old infection. In old infection or vaccination, there was no significant difference between positive and negative cases as regard to age, gender or socioeconomic status. However, there was significant increase of previous vaccination in positive cases (3.1%) when compared to negative cases (0.0%) and significant increase of positive IgM in negative IgG cases. In addition, there was significant increase of liver enzymes in cases negative for IgG when compared to positive cases. There was high endemicity of hepatitis A virus infection in school age children. The active infection reported in minor percentage and the condition was self-limiting. Thus, most positive cases were not vaccinated or had active clinical infection. Seroconversion is due to subclinical infection. Thus, IgG and IgM estimation must be done before vaccination.
机译：这项研究的目的是评估达米埃塔省6-12岁学生中IgM抗HAV的患病率，并确定与该感染率相关的因素。本研究包括1000名6-12岁的儿童。选自儿科门诊;不论其接种史如何。他们是在2012年9月至2014年9月期间选定的。记录了以下与身份和社会人口统计学特征有关的数据：个体性别，年龄，居住，家庭成员数量，房间数量，在该地区一起睡的人数相同的房间，家庭收入，父母或监护人的教育程度，自来水供应的可用性，污水的存在以及房屋中浴室的存在和数量。然后估计IgG和IgM。年龄范围为6至12岁，平均为8.87±1.95岁;男性占56.7％，农村地区占66.4％，社会经济水平低下占46.5％，中等水平占24.2％。先前报告的疫苗接种率为2.7％，活动感染的报告率为1.9％，先前（旧）感染或疫苗接种的报告率为86.5％。最后，ALT病例的范围为8-65 IU mL -1 ，平均值为12.53±5.40 IU mL -1 ，AST的病例为8-29 IU，平均值为12.07 ±2.56 IU mL -1 。阳性病例较年轻（分别为7.94±2.09和8.89±1.94）。低社会经济标准（37.7％）的ALT和AST明显较高。主动感染组未曾接种过疫苗或曾感染旧疫苗。在旧的感染或疫苗接种中，阳性，阴性病例在年龄，性别或社会经济状况方面均无显着差异。然而，与阴性病例（0.0％）相比，阳性病例（3.1％）的先前疫苗接种显着增加，阴性IgG病例的IgM阳性显着增加。此外，与阳性病例相比，IgG阴性的肝酶显着增加。在学龄儿童中，甲型肝炎病毒感染的流行率很高。主动感染的报道比例很小，病情是自限性的。因此，大多数阳性病例没有接种疫苗或有活跃的临床感染。血清转化是由于亚临床感染。因此，必须在接种疫苗之前进行IgG和IgM评估。

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