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首页> 外文期刊>Journal of Medical Sciences >25-Hydroxyvitamin D3 Level in Patients with Chronic Viral Hepatitis B
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25-Hydroxyvitamin D3 Level in Patients with Chronic Viral Hepatitis B

机译：乙型病毒性肝炎患者25-羟维生素D 3 水平

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Vitamin D is an important immune modulator that has an emerging role in inflammatory and metabolic liver diseases. An association has been established between low levels of vitamin D and several adverse health outcomes including upper respiratory and enteric infections, viral hepatitis and HIV infections. It exerts protective effects during infections by up-regulating the expression of cathelicidin and β-defensin 2 in phagocytes and epithelial cells. Thus, vitamin D appears to have systemic antimicrobial effects that may be crucial in a variety of both acute and chronic illnesses. In the current study, 25-hydroxyvitamin D3 (25-OHD3) levels were compared among 75 patients with chronic hepatitis B virus infection (Group I), sixty naturally immunized individuals (Group II) and another sixty age and sex-matched healthy controls. Routine biochemical parameters like hepatitis markers, hepatitis B virus serology, hepatitis B virus DNA, 25-OHD3 and Parathormone levels were measured. Patients in group I had a significantly lower 25-OHD level compared with group II and controls (13.9±4.93 vs. 22.1±6.14 and 23.15±8.28 ng mL-1, respectively p-1, respectively p<0.001). Also, 25-OHD levels were inversely correlated with hepatitis B virus DNA levels. The observed diminished 25-OHD levels in patients infected with hepatitis B virus may be an indicator of the viral replication status and portends a poor prognosis.
机译：维生素D是重要的免疫调节剂，在炎症性和代谢性肝病中起着新的作用。维生素D含量低与几种不良健康后果之间已建立关联，包括上呼吸道和肠道感染，病毒性肝炎和HIV感染。它通过上调吞噬细胞和上皮细胞中cathelicidin和β-defensin2的表达在感染过程中发挥保护作用。因此，维生素D似乎具有全身性的抗菌作用，这在各种急性和慢性疾病中都可能至关重要。在本研究中，比较了75例慢性乙型肝炎病毒感染患者（I组）中的25-羟基维生素D 3 （25-OHD 3 ）水平，其中60例自然免疫个人（第二组）和另外六十个年龄和性别相匹配的健康对照组。测量了常规生化参数，如肝炎标志物，乙型肝炎病毒血清学，乙型肝炎病毒DNA，25-OHD 3 和副激素水平。与第二组和对照组相比，第一组患者的25-OHD水平显着降低（分别为13.9±4.93和22.1±6.14和23.15±8.28 ng mL -1 ，p-1 分别为p <0.001）。同样，25-OHD水平与乙型肝炎病毒DNA水平成反比。在乙型肝炎病毒感染患者中观察到的25-OHD水平降低可能是病毒复制状态的指标，预示不良预后。

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