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首页> 外文期刊>Journal of Medical Sciences >Efficacy of 10% Azelaic Acid Gel with Hydro-alcoholic or Alcohol-free Bases in Mild to Moderate Acne Vulgaris; the First Clinical Trial
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Efficacy of 10% Azelaic Acid Gel with Hydro-alcoholic or Alcohol-free Bases in Mild to Moderate Acne Vulgaris; the First Clinical Trial

机译：轻度至中度寻常型痤疮中10％壬二酸凝胶与水醇或无醇碱的功效;第一次临床试验

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Azelaic Acid is a very effective topical medication for treating acne vulgaris. This study aims to compare the efficacy of 10% azelaic acid gel with hydro-alcoholic and alcohol-free bases in mild-to-moderate acne vulgaris. This randomized, double blind, clinical trial, 40 patients with mild-to-moderate acne vulgaris were recruited from Sina Hospital from November 2009 through March 2011. They randomized in two equal age and sex-matched groups, receiving 10% azelaic acid gel with either hydro-alcoholic base or alcohol-free base once at night on their face for eight consecutive weeks. All the patients were revisited on weeks 1, 2, 4, 6 and 8 after treatment and facial acne lesions were counted on each session. Possible complications, as well as the effect of skin type were investigated. Total, inflammatory and noninflammatory acne lesion counts decreased significantly in both groups by the end of study period. However, there was no significant difference between the two groups in this regard (p<0.05). There were minor, self-limited complications, including 3 cases of mild itching in both groups. For the count of inflammatory lesions, azelaic gel with alcoholic base was significantly more effective than azelaic gel with alcohol-free base in patients with oily facial skin (p = 0.02). All the patients (100%) were very satisfied with their treatments. In conclusion, both 10% azelaic gels with hydro-alcoholic and alcohol-free bases were comparably effective against mild-to-moderate acne vulgaris. In patients with oily skin, however, 10% azelaic acid with hydro-alcoholic base was superior to the medication with alcohol-free base in patients with oily skin.
机译：壬二酸是治疗寻常痤疮的非常有效的局部用药。这项研究的目的是比较10％壬二酸凝胶与轻，中度寻常痤疮中的水，酒精和无酒精碱的功效。该随机双盲临床试验从2009年11月至2011年3月从新浪医院招募了40例轻度至中度寻常型痤疮患者。他们随机分为两个年龄和性别匹配的组，接受10％壬二酸凝胶和晚上一次连续8周在脸上涂一次水，酒精或无酒精的碱。在治疗后的第1、2、4、6和8周对所有患者进行了再次检查，并在每次疗程中对面部痤疮病变进行计数。研究了可能的并发症以及皮肤类型的影响。到研究期结束时，两组痤疮的总，炎性和非炎性痤疮病变计数均显着降低。但是，在这方面，两组之间没有显着差异（p <0.05）。有轻微的，自限性并发症，两组均包括3例轻度瘙痒。对于炎性病变的计数，油性面部皮肤患者含酒精基的壬二酸凝胶比不含酒精基的壬二酸凝胶要有效得多（p = 0.02）。所有患者（100％）对他们的治疗都非常满意。总之，含10％的壬二酚凝胶和含水醇和不含酒精的碱对轻度至中度寻常性痤疮具有相当的效果。然而，在油性皮肤患者中，含油性乙醇的10％壬二酸优于油性皮肤患者的含无酒精碱的药物。

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