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首页> 外文期刊>Journal of Medical Sciences >Relationship between Angiotensinogen gene T174M Polymorphism and Essential Hypertension in a Sample of Algerian Population: Case Control Study
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Relationship between Angiotensinogen gene T174M Polymorphism and Essential Hypertension in a Sample of Algerian Population: Case Control Study

机译：阿尔及利亚人群样本中血管紧张素原基因T174M多态性与原发性高血压的关系：病例对照研究

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Essential hypertension is a multifactorial complex trait. It affects around one billion people worldwide. Many genes have been incriminated in its onset. This study aimed to determine the association of the AGT T174M gene variant with essential hypertension in a sample of Algerian population of the Oran city. In this study, we involved 350 subjects, 180 hypertensives and 170 normotensives. Consents were obtained from all the participated subjects. Polymerase Chain Reaction (PCR) combined with Restrictive Fragment Length Polymorphism (RFLP) was used to detect the T174M variant of angiotensinogen (AGT) gene. Blood pressure, body height and weight, fasting blood glucose and serum lipid were measured in all subjects. The genotypic and allelic distribution of the T174M variant of the AGT gene did not differ in hypertensives and normotensives group (OR = 1.05; 95% CI [0.583-1.932]; χ2 = 5.298; p>0.05; χ2 = 5.692; p>0.05), where the frequency of genotypes in the patient with essential hypertension was TT: 64.4%; TM: 20.5%; MM: 15% vs. TT: 55.8%; TM: 19.4%; MM: 24.7% for the controls. The allelic frequency was 0.7 vs. 0.66 for the T allele and 0.26 vs. 0.34 for the mutant allele in hypertensives and controls, respectively. This study shows that the T174M variant of the AGT gene is not associated with essential hypertension in this sample of Algerian population of the Oran city.
机译：原发性高血压是一种多因素的复杂性状。它影响了全世界约十亿人。许多基因在发病时就已被证实。这项研究旨在确定奥兰城阿尔及利亚人口样本中AGT T174M基因变异与原发性高血压的关系。在这项研究中，我们涉及350名受试者，180名高血压和170名正常血压。从所有参与的受试者中获得同意。聚合酶链反应（PCR）结合限制性片段长度多态性（RFLP）用于检测血管紧张素原（AGT）基因的T174M变体。在所有受试者中测量血压，身高和体重，空腹血糖和血清脂质。高血压组和正常血压组中AGT基因T174M变体的基因型和等位基因分布无差异（OR = 1.05; 95％CI [0.583-1.932];χ 2 = 5.298; p> 0.05 ;χ 2 = 5.692; p> 0.05），其中原发性高血压患者的基因型频率为TT：64.4％; TM：20.5％; MM：15％; TT：55.8％; TM：19.4％; MM：对照组为24.7％。在高血压和对照中，T等位基因的等位基因频率分别为0.7 vs. 0.66和0.26 vs. 0.34。这项研究表明，在奥兰市的阿尔及利亚人口样本中，AGT基因的T174M变体与原发性高血压无关。

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